Abelian-Tatarin Reaction

Abelev-Tatarinov reaction

The Abelev-Tatarinov reaction is an immunological reaction developed by Soviet scientists Grigory Ivanovich Abelev and Yuri Sergeevich Tatarinov in 1959.

Grigory Ivanovich Abelev (born in 1928) - Soviet immunologist, academician of the USSR Academy of Sciences. Yuri Sergeevich Tatarinov (born in 1928) - Soviet biochemist, corresponding member of the USSR Academy of Sciences.

The essence of the reaction is that when antibodies interact with complement, antibody-complement complexes are formed, which are precipitated with polyethylene glycol. This makes it possible to quantify antibodies in the blood serum.

The Abelev-Tatarinov reaction is widely used in immunology and allergology to detect antibodies, in particular in the diagnosis of infectious and autoimmune diseases. It has high sensitivity and specificity.

Thus, the Abelev-Tatarinov reaction is an important immunological method developed by outstanding Soviet scientists and widely used in medical practice.

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G. I. Abelev (1905–1964) - Soviet immunologist, creator of the Abelian reaction and one of its researchers. In 1946, together with Yu. S. Tatarinov, G. I. discovered the reaction of the formation of an antigen complex with immunoglobulin on a phospholipid membrane or other matrices. Let us call the discovered reaction the “Abelian reaction” in honor of its discoverers G. A. Benediktov and V. L. Abekamyan, participants in the famous Abel desaturation experiment. The mentioned experiment was the first to suggest the possibility of forming antibodies on artificial matrices similar to humoral protective factors. The experiments were not full-fledged stages of the study, however, they made a significant contribution to the search for methods for studying immunogenesis. Let us write down the Abelian reaction, starting with two known immunological processes: firstly, an immunogen from a protein, and secondly, the introduction of an antigen, which indicates the associativity between them. It is very likely that immune reactions on polysalt films are of the same importance for the detection of antigens as the process of antigen adsorption on a protein during the atelioscopic method. Samples of polysalt films have the specificity of a countercation, therefore both the biocation, which included the antigen, and the protein film became heterogeneous, but immunologically related, on which the Abelian immunoodes is based, i.e. reaction on polysalt film. Without going deeper into the chemical aspect of the Abelian method, we note only the essential characteristics of this complex method for studying antigens: - high sensitivity; - sensitivity as a reactivation form in the process of antibody synthesis; - the ability to study the transfer reaction through many phases of the process (conformation, etc.); - the question of the conformational lithium of the antigen is excluded; - obtaining a sample good for long-term storage or preservation (practical significance). The Abel reaction should be taken into account as an element of antibody synthesis, and not as the formation of antibodies within their synthesis, since the most effective stage in the creation of antibodies is associated with the transfer reaction of the immune system. Let us analyze the specific experiment that its authors analyzed; Taking into account the results of Tatarinov and Abelev’s research, we consider its results as a clear demonstration of Abel’s method of using antigen for immune protection. The history of setting up the Abelian method is proposed

The Abelev-Tatarinov reaction (also known as the Tatarinov-Abelev reaction) is a key reagent for DNA binding and makes it possible to study the structure of this macromolecule at high concentrations. This reaction is a reaction where the hydroxyl group (–OH) of an organic molecule such as ammonia is replaced by the hydroxylate terminal oxygen atom in a DNA molecule. The main aspects of studying the Abelev-Tatarinova reaction do not depend on the type of bond in DNA - known combinations of thymine-thymine bases, thymine-guanine and guanine-guanium bases can give different reactions. The behavior of some types of Abelevsky-Tataranovo reaction could be seen in previous studies, it was found that adenosine is not a major component of DNA modification as originally thought, since almost half of adenine undergoes the Abelevsky-Tataranovo reaction in some cases. The modified adenine is also able to bind to the protein fiber and may have some effect on DNA replication and transcription, while the protein-DNA complex interferes with the clearance of fragments from DNA terminal endonuclease (eg, enzymes). As mentioned previously, a higher concentration of DNA (700 micrograms per milliliter, diluted in 4 ml) is capable of producing high-level signals when monitoring the Tatarin-Abelline reaction. To solve the problems associated with the Tatarin-Azevelli reaction, the following improvements are required. First, additional studies must be conducted to identify specific conditions to understand the mechanism that occurs in the Abeliev-Tatarin reaction. Secondly, it may be necessary to control the analysis conditions - temperature, pH, sample size. In this case, it becomes possible to use this method not only for scientific purposes, but also for clinical diagnostics.