Acetylsalicylic acid

Acetylsalicylic acid

Country of origin: Russia, ICN Marbiopharm Russia, ICN October Russia, ICN Polypharm Russia, ICN Tomskkhimpharm Russia, Akrikhin KhFK Russia, Altaivitamins Russia, Analytical and Management Group Russia, Antiviral Russia, Asfarma Russia, Belvitamins Russia.

Pharmaceutical group: Anti-inflammatory drugs - derivatives of salicylic acid.

Manufacturers: AI CN Leksredstva (Russia), AI CN Marbiofarm (Russia), AI CN Oktyabr (Russia), AI CN Polypharm (Russia), AI CN Tomskkhimpharm (Russia), Akrikhin HFC (Russia), Altaivitamins ( Russia), Analytical and Management Group (Russia), Antiviral (Russia), Aspharma (Russia).

International name: Acetylsalicylic acid.

Synonyms: HL-Pain, Anopyrin, Apo-Asa, Aspecard, Aspivatrin, Aspicor, Aspilight, Aspirin, Aspirin "York", Aspirin "Quality", Aspirin 1000, Aspirin for children, Aspirin cardio, Aspirin UPSA, Aspirin-Direct, Aspitrin , Aspomay, Aspro 500, ACC-Ratiopharm, Acenterin, Acesal.

Dosage forms: substance, tablets 500 mg, tablets 250 mg, tablets for children 100 mg, tablets 100 mg, tablets 325 mg, substance 500 g, substance 1 kg.

Composition: Active substance - acetylsalicylic acid.

Indications for use: Rheumatism, rheumatoid arthritis, infectious-allergic myocarditis; fever in infectious and inflammatory diseases; pain syndrome of various etiologies: headache (including those associated with alcohol withdrawal syndrome), migraine, toothache, neuralgia, myalgia, arthralgia, algomenorrhea; thrombosis and thromboembolism (prevention), myocardial infarction (secondary prevention), coronary heart disease, unstable angina, cardiac arrhythmias, etc.

Contraindications: Hypersensitivity, erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, gastrointestinal bleeding; "aspirin" asthma; bleeding disorder, vitamin K deficiency, severe renal failure, first trimester of pregnancy, lactation. It is prescribed with caution to patients with gout, liver diseases, and children under 12 years of age with hyperthermia due to viral diseases.

Side effects: Nausea, anorexia, gastralgia, diarrhea, erosive and ulcerative lesions, bleeding in the gastrointestinal tract; allergic reactions (skin rash, bronchospasm); renal and/or liver failure; thrombocytopenia. With long-term use - dizziness, headache, reversible visual impairment, tinnitus, vomiting, bleeding, etc. Decreased sense of hearing acuity, tinnitus, severe headaches - in high doses. In predisposed patients - bronchospasm.

Interaction: Strengthens the effect of heparin, oral anticoagulants, reserpine, steroid hormones and oral antidiabetic agents. Reduces the effect of antihypertensive drugs. Simultaneous administration with other non-steroidal and anti-inflammatory drugs, methotrexate increases the risk of side effects.

Overdose: Symptoms: salicylic syndrome (nausea, vomiting, tinnitus, general malaise, fever - a poor prognostic sign in adults). More severe poisoning - stupor, convulsions and coma, non-cardiogenic pulmonary edema, acid-base imbalance, liver failure.

Special instructions: 5-7 days before surgery, it is necessary to stop taking the drug (to reduce bleeding during surgery and in the postoperative period). During long-term therapy, it is recommended to regularly perform blood tests and examine stool for occult blood.

Literature: Encyclopedia of Medicines, 9th edition, 2002. Medicines M.D. M

Acetylsalicylic acid

Acetylsalicylic acid has a selective psychotropic and hematotoxic (anticoagulant) effect.

In case of an overdose, symptoms such as dizziness, tinnitus, hearing loss, visual disturbances, agitation, and euphoria are observed. There is noisy, rapid breathing. Delirium, stuporous state, and coma may develop. Subcutaneous hemorrhages, nasal, gastrointestinal and uterine bleeding may occur.

Complications of overdose are methemoglobinemia, toxic nephropathy, metabolic acidosis, peripheral edema. The lethal dose for adults is about 30-40 g, for children - about 10 g.

Treatment of overdose includes gastric lavage, the introduction of activated carbon and vaseline oil orally, forced diuresis, blood alkalization, early hemodialysis and hemosorption. To stop bleeding, vikasol and calcium chloride are administered. Diazepam is used to relieve agitation. If methemoglobinemia develops, treatment is similar to the treatment of aniline poisoning.