Ahilia Stomach Histamine-resistant

Histamine resistance is the preservation of gastric achylia when histamine is introduced into the body, which is a stimulator of the secretion of hydrochloric acid from the cells of the stomach, which is determined during a histamine test. Clinically, this phenomenon is manifested by asymptomatic ulcers of the stomach and duodenum, treatment-resistant gastric and duodenal ulcers, as well as the development of severe forms of erosive gastroduodenal ulcers.

Gastric achylia is a pathological condition that is characterized by a lack of gastric juice, acidity and peristalsis of the stomach muscles. This can be caused by various reasons, such as genetic predisposition, digestive disorders, peptic ulcers, stress, surgery and other diseases. When a person experiences achylia, they may experience symptoms such as abdominal pain, nausea, vomiting, constipation, or diarrhea. Treatment for gastric achylia may include lifestyle changes, drug therapy, and surgery.

One of the most common types of achilia is histamine-resistant achilia. Histatin-resistant is a condition when the stomach does not respond to stimulation with histaline, one of the main hormones that regulates the secretion of hydrochloric acid. This achylia is determined not only by an insufficient volume of gastric secretion, but also by a low histamine content in saliva and gastric contents. Histamine resistance in Achilia occurs due to errors that occur in the stomach during the processing of histaline.

With histatinous achylia, it is important to understand the reason that led to the development of this condition. To do this, it is necessary to conduct a comprehensive examination with a doctor who can help determine the necessary treatment methods. Diagnosis includes blood tests

Histamine is one of the most important mediators in the regulation of the secretory function of gastric cells. There are two main types of stomach cells: chief and parietal. The chief cell functions to produce pepsin and mucus, while the parietal cell secretes gastrin, which stimulates the production of pepsin by the chief cells. Gastrin stimulates the contraction of chief cells, which helps move food through the stomach for further digestion. Stimulation of gastric secretions occurs through various factors, including food intake, chemical stimulus, or nerve signals. However, sometimes the stomach may not respond to this stimulus, resulting in gastric achylia (lack of acid and enzymes in the stomach). One of the variants of achylia is achylia gastric histamine resistance (A.Zh.G.), which is characterized by the preservation of normal acidity and the functional state of the stomach cell during histamine stimulation.

One of the reasons A.Z.G. is a genetic mutation in the hydrochloric acid regulator (HClR) gene, which encodes the histamine H2 receptor. This receptor is a protein found on the surface of stomach cells, and the binding of histamine to this protein receptor leads to stimulation of gastric secretory activity. In gastric achylia histamine refractoriness, the level of histamine and cellular secretion persists even after stimulation with histine, which may indicate a lack of sensitivity of the histamine receptor to histamine stimulation.

To prevent the development of A. Zh.G. Regular checks and monitoring of stomach health are necessary. To do this, you can use methods such as gastroscopy, testing the level of histamine in the blood, analyzing the content of hydrochloric acid in feces (HC) and testing the acidity of gastric juice. In addition, you should avoid exposure to factors such as smoking, chronic alcohol consumption and long-term stress that may contribute to the development of the disease. Treatment of AD. G. may include protective drugs, such as proton pump inhibitors or selective histamine receptor blockers, as well as lifestyle changes to reduce the negative impact of risk factors. In any case, it is important to consult a doctor for timely diagnosis and treatment of achylia gastric histabinoma.