Ariboflavinosis

**Ariboflavinoses** are a group of various metabolic disorders (enzymopathies) caused by insufficient activity of one of the enzymes: flavin protein kinase, involved in the metabolism of riboflavin (vitamin B2), flavoprotein, flavin adenine dinucleotide (FAD) and pyridoxal phosphate, catalase. Deficiency of any of these enzymes leads to a decrease in the use of pyridoxaminoglutamate, glutamic acid, glycine and other amino acids.

Functionally, riboflavins are not identical to each other and differ only in their side chains; however, due to their similarities, they all combine with the center of the flavin molecule and form a complex called a prosthetic group (oxidation site). There are two forms of riboflavins: active (avidin) and inactivated (flavin). Riboflavin is a powerful synergistic coenzyme. This enzyme is involved in many metabolic reactions, including the synthesis of hemoglobin, protein, heterocyclic group of amino acids, the formation of active forms of vitamin C in pigment, etc. Deactivated and avidin are less active forms of riboflavin. In some patients they can be effective anticonvulsants. A similar enzyme, butyrophenones and riboxyhydrofluorate, participate together in the redox processes of the central nervous system. When riboflavit levels are elevated, the patient may have trimethylglycine in the urine, and less commonly, oxaloacetate. Cortisol levels remain normal. Oddly enough, a low concentration of cortisol may indicate the presence of a deficiency state of the body in B vitamins. The level of folic acid in the blood is increased.