Blood Pleural Barrier

Blood-pleural barriers (BPB) are physiological barriers that are located at the border of blood and surrounding tissues in the body. They play an important role in regulating metabolism and protecting against various harmful factors. In this article we will look at what blood-pleural barriers are and how they function in the human body.

The hematopleurological barrier was first described in 1942 in the works of such scientists as M. N. Martsinovsky and A. S. Glazunov. Blood-pleurological barriers protect the vascular system from a variety of factors, including microbes, cellular waste products, plasma proteins, blood, hormones, and metabolites. They also control the amount of substances penetrating from the blood into surrounding tissues and vice versa, and also ensure the isolation of blood vessels from each other and protection from damage.

The GPB consists of hematin, a component of hemoglobin in the blood, and mesangium, the tissue located between the bundles of blood capillaries. This tissue contains fibroblasts, microvessels and collagen fibers. Hematin binds fibroblastic cells, vessels, and pericytes together to form a continuous film that protects adjacent capillaries from damage.

Since hematople

Hematopleura is a commissure formed by the vessels of the mediastinum and pleura with parietal and transverse sections of the visceral and parietal layer of the pleura

The main functional element of the histohematic barrier and the barrier associated with it is the endothelium, which ensures selective membrane permeability through endocytic and transmembrane channels. Their blocking occurs due to ischemia, changes in fluid inflow/outflow, microbial inflammation or intoxication. Endotheliocytes are capable of generating receptors for blood cell adhesion. Membrane elements include collagen, proteoglycans, glycocalyx and adhesion molecules. Apparently, the same molecular mechanisms are important as for maintaining the integrity of endothelial tissues. Endocytosis of damaged plasma membranes prevents stromal injury beneath the endothelium

Pathophysiology. Disturbances of the hematoma in an isolated state are rarely observed; most often they are accompanied by some kind of respiratory disease. The pleura, diaphragm, mediastinum and pericardium are affected. Course of hematomupleuritis 5. Granular serous exudate: intimal fibrin threads, many neutrophilic leukocytes, sometimes thrombotic clots may be visible, the thrombus may also contain erythrocytes (monetary bodies). Cellular composition: neutrophils, eosinophils. Inflammation of the basement membrane is possible in individuals with significant vitamin C deficiency. It is characterized by degeneration of the basal layers of mesenchymal and epithelial cells of the pleural layers and some bronchial linings, as well as damage to the myoid structures of the diaphragms