Claforan

Claforan: use, side effects and contraindications

Claforan is a third-generation cephalosporin drug that is used to treat severe bacterial infections. The active substance of the drug is cefotaxime.

Manufacturers of Claforan - Laboratory Roussel (France), Laboratory Roussel (Italy), Laboratory Roussel (Spain), Laboratory Roussel Diamant (Hoechst Marion Roussel) (France), Laboratory Roussel Diamant (Hoechst Marion Roussel), packaged by Pharmfirm "Sotex" (France/ Russia), Roussel.

Klaforan is available in powder form for the preparation of injection solutions in various dosages (0.5 g and 1 g). The drug is used to treat severe infections caused by sensitive microorganisms, such as infections of the respiratory tract and ENT organs, infections of the skin and soft tissues, infections of bones and joints, infections of the urinary tract, pelvic organs, obstetric and gynecological infections, bacteremia, septicemia, peritonitis , intra-abdominal infections, bacterial meningitis, endocarditis, Lyme disease, typhoid fever and infections associated with immunodeficiency. In addition, Claforan can be used to prevent infections after surgery, including operations on the gastrointestinal tract.

Despite its effectiveness, Claforan has some contraindications and side effects. The drug is not recommended in case of hypersensitivity to penicillins, other cephalosporins or carbapenems, as well as during pregnancy, breastfeeding and children under 2.5 years of age for intramuscular administration. Restrictions on use include a history of enterocolitis and chronic renal failure.

Side effects of Claforan may include headache, dizziness, cardiac arrhythmias, neutropenia, transient leukopenia, granulocytopenia, eosinophilia, thrombocytopenia, agranulocytosis, hypoprothrombinemia, autoimmune hemolytic anemia, nausea, vomiting, abdominal pain, diarrhea/constipation, flatulence, dysbacteriosis, transient increased activity of liver transaminases, LDH, alkaline phosphatase and bilirubin in the blood plasma. Rarely, allergic reactions, including anaphylactic shock, may occur.

Before starting treatment with Claforan, it is necessary to test the sensitivity of microorganisms to the drug in order to avoid unnecessary use and the development of resistance in bacteria.

Claforan is injected intravenously or intramuscularly. The dosage and duration of treatment depend on the severity of the infection, age and condition of the patient. Usually the drug is used 1-2 times a day for 7-14 days.

If side effects occur, you should consult your doctor and, if necessary, interrupt treatment with Claforan.

In general, Claforan is an effective and widely used drug for the treatment of severe bacterial infections, but its use should be carried out only as prescribed by a doctor and in compliance with all recommendations and restrictions.