Clafotaxime

Clafotaxime: Third generation cephalosporin from India

Clafotaxime (international name Cefotaxime) is a representative of the third generation cephalosporins, widely used in medicine to combat bacterial infections. This drug is manufactured in India by San Pharmaceuticals Industries Ltd.

Clafotaxime has various synonyms, such as Bayotax, Duatax, Intrataxime, Kefotex, Clafobrine, Claforan, Liforan, Oritaxime, Resibelacta, Sephagen, Spirosine, Taxim, Talcef, Tarcefoxime, Tirotax, Haltex, Cetax, Cephabol, Cephajet, Cephantral, Cefosin, Cefotaxime , Cefotaxime sodium, Cefotaxime-MD.

The dosage form of Clafotaxime is a powder for the preparation of an injection solution. Its active substance is cefotaxime.

Clafotaxime is used to treat severe bacterial infections caused by susceptible microorganisms. It is effective for infections of the respiratory tract and ENT organs (except enterococcal infections), skin and soft tissues (including infected wounds and burns), bones and joints, urinary tract, pelvic organs, as well as in gynecology and obstetrics (including chlamydia, gonorrhea, caused by microorganisms that secrete penicillinase). It is also effective in bacteremia, septicemia, peritonitis, intra-abdominal infections, bacterial meningitis (except listeria), endocarditis, Lyme disease, typhoid fever and infections associated with immunodeficiency. In addition, Clafotaxime can be used to prevent infections after surgery, including gastrointestinal surgery.

Clafotaxime has some contraindications. It is not recommended to use it in case of hypersensitivity to penicillins, other cephalosporins and carbapenems, as well as during pregnancy, breastfeeding and in children under 2.5 years of age (for intramuscular administration). It should also be used with caution if there is a history of enterocolitis and chronic renal failure.

Side effects from the use of Clafotaxime may include headache, dizziness, cardiac arrhythmias (the following side effects may occur when using Clafotaxime:

1. Allergic reactions: urticaria, itching, rash, angioedema (swelling of the face, lips, tongue, larynx), anapaphylaxis (severe allergic reaction).
2. Digestive system: diarrhea, nausea, vomiting, dysbiosis, pseudomembranous colitis (inflammation of the intestines caused by Clostridium difficile).
3. Blood: impaired blood formation (thrombocytopenia, leukopenia), eosinophilia, agranulocytosis (decreased number of granulocytes in the blood).
4. Liver: increased activity of liver enzymes (ALT, AST), hepatitis.
5. Kidneys: increased creatinine levels in the blood, anuria (lack of urination).
6. Nervous system: headache, dizziness, sleep disturbance, increased excitability, convulsions.
7. Skin: itching, rash, skin redness, photodermatitis.
8. Cardiovascular system: cardiac arrhythmia, low blood pressure, vasculitis.
9. Others: anemia, increased levels of bilirubin in the blood, increased activity of liver enzymes, alopecia (hair loss).

If you experience any side effects or unusual symptoms while using Clafotaxime, it is important to contact your doctor for advice and advice. The doctor will be able to assess your situation and take appropriate measures.