Duffy Isoantigens

Duffy isoantigens are rare protein molecules that can be found on the surface of red blood cells in some people. They are named after the first patient with such a genetic disorder - a patient named Duffy.

Scientists have found that the presence or absence of Duffy isoantigens is associated with resistance to certain infections. In particular, people with African ancestry who lack these isoantigens are more likely to contract malaria. This is because Plasmodium, which causes malaria, uses Duffy isoantigens to enter red blood cells.

On the other hand, the absence of Duffy isoantigens may be beneficial for people living in the southern United States, where malaria is not common. These people have an increased resistance to infections caused by bacteria such as Helicobacter pylori, which can cause stomach ulcers.

Duffy's research into isoantigens continues, and scientists hope they can use this knowledge to develop new methods for preventing and treating infectious diseases. This may also be important information for people planning to travel to a part of the world where certain infections are common.