Dermestril

Country of origin - Italy
Pharm-Group - Estrogen products

Manufacturers - Rottafarm S.p.A. (Italy)
International name - Estradiol
Synonyms - Divigel, Klimara, Menorest, Estraderm TTS 100, Estraderm TTS 25, Estraderm TTS 50, Estradiol dipropionate, Estradiol dipropionate, Estrimaks, Estrogel, Estrofem
Dosage forms - 25mcg, 50mcg, 100mcg
Composition - Active ingredient - Estradiol.

Indications for use - Estrogen deficiency during menopause and after gynecological operations, delayed puberty in girls, alopecia with hyperandrogenemia, hirsutism with polycystic ovary syndrome, weakness of labor, primary biliary cirrhosis in women, uterine bleeding, postcoital contraception, migraine and prevention osteoporosis in premenopausal women, breast cancer in men and women with metastases (palliative therapy), prostate carcinoma (palliative therapy).

Contraindications - Hypersensitivity, cancer of the uterus, ovaries, breast, estrogen-dependent neoplastic processes, endometriosis, dysfunction and liver tumors, diabetes mellitus (insulin-dependent, with vascular damage), sickle cell anemia, herpes, otosclerosis with hearing impairment, jaundice or constant itching during previous pregnancy, undiagnosed uterine bleeding, thrombophlebitis and thromboembolic conditions (including a history), pregnancy, breastfeeding.

Side effects - Headache, dizziness, depression, migraine, chorea, blurred vision (changes in corneal curvature), increased blood pressure, thromboembolism, nausea, vomiting, epigastric pain, flatulence, cholestatic hepatitis, cholelithiasis, uterine bleeding, endometrial hyperplasia, increase in the size of the uterus, fibrous changes in the myometrium, vaginal candidiasis, thickening and enlargement of the breasts, changes in libido, edema, weight gain, decreased tolerance to carbohydrates, attacks of porphyria, chloasma, melasma, contact dermatitis, itching and hyperemia of the skin (at the site of application of the patch) , allergic reactions.

Interaction - The effect is reduced by narcotic analgesics, tranquilizers, anesthetic and anticonvulsant drugs, inducers of microsomal liver enzymes. Reduces the activity of antihypertensive, anticoagulant and hypoglycemic drugs.

Overdose - Symptoms: nausea, vomiting and in some cases - uterine bleeding. Treatment: maintenance of vital functions (during drug withdrawal).

Special instructions - During long-term therapy, a preventive examination is required at least once a year.

Literature - Encyclopedia of Medicines 2004