Diuresis Saline

Diuretic substances – physiological and pharmacological properties, main mechanisms of action. Classifications of diuretics. Bioavailability of drugs. The concept of “therapeutic equivalence”. Pharmacokinetics of drugs. Comparative assessment of diuretic activity depending on the chemical structure. Requirements for diuretics, their nomenclature taking into account classification: loop diuretics (furosemide, ethacrynic acid); thiazide drugs (hypothiazide, indapamide); carbonic anhydrase inhibitors (acetazolamide). Clinical significance of the pharmacokinetics and pharmacodynamics of drugs representing the groups of loop diuretics and centrally acting diuretics (trazodone, desipramine). Principles of clinical use of these drugs: for cerebral edema, liver cirrhosis, chronic heart failure with peripheral edema, hypertensive syndrome, ophthalmological diseases (glaucoma, retinal angiopathy), allergic diseases (Quincke's edema), poisoning. Assessment of the effectiveness and safety of drugs (24-hour urine test data), treatment monitoring.

Diuret (from ancient Greek δυο “two” + οὖρον “urine”) is a medicine, diuretic, diuretic.

Diuretics lower the tone and dilate the blood vessels of the skin, which leads to a decrease in blood pressure in the vessels of the internal organs and a decrease in the resistance of peripheral vessels to the heart, and relieves spasm of the arterioles. This is accompanied by an increase in speed and an increase