Erythropoiesis (Erythropoiesis, Erythrogenesis)

Erythropoiesis (Erythropoiesis, Erythrogenesis) is the process of formation of red blood cells, which usually occurs in the hematopoietic tissue of the bone marrow. The initial precursor of the erythrocyte is the hematopoietic stem cell, and the morphologically identifiable precursor, identified during microscopic examination, is the proerythroblast. It divides, passing through a number of stages during its maturation; at these stages these cells are called basophilic, polychromatophilic erythroblasts and normoblasts respectively, the latter eventually losing their nucleus and becoming a mature red blood cell.

See also Hematopoiesis.

Erythropoiesis is the process of formation of red blood cells. It occurs in the hematopoietic cells of the bone marrow, which divide into a series of stages before becoming mature red blood cells.

The source cell for erythropoiesis is a hematopoietic stem cell. It divides to produce basophilic, polychromophilic erythroblastic cells and normoblasts. At the basophilic cell stage, the cell nucleus becomes more compact and basophilic (hence the name). In the next stage of polychromophily, the nucleus becomes lighter and polychromatic. Finally, at the normoblast stage, the nucleus disappears and the cell becomes a mature erythrocyte.

Erythropoiesis is important for maintaining healthy blood and maintaining the body's oxygen balance. It also plays an important role in the immune system because red blood cells contain iron, which is necessary for the production of hemoglobin.

The process of erythropoiesis can be impaired as a result of various diseases and conditions, such as anemia, myelodysplasia, hemolysis and others. Therefore, understanding the processes of erythropoiesis and its regulation is important for the diagnosis and treatment of these conditions.

Erythropoiesis is the process of formation of red blood cells in the human body, which occurs in the hematopoietic cells of the bone marrow and is regulated by hormones and growth factors. During the process of erythropoiesis, the maturation and differentiation of erythrocyte precursors from more primitive stem cells occurs.

The initial precursor for the formation of red blood cells is a hematopoietic stem cell, which divides and goes through various stages of maturation to become a mature red blood cell. The morphologically identifiable precursor, the proerythroblast, is divided into basophilic erythroblastic cells, polychromatophilic erythroblastic cells, and normoblasts. Normoblasts eventually lose their nucleus and become mature red blood cells.

Erythropoiesis is regulated by various hormones, such as erythropoietins, which stimulate the formation of new red blood cells. In addition, the rate of erythropoiesis is regulated by growth factors such as thrombopoietin and interleukin-3.

The process of erythropoiesis is important for maintaining normal levels of hemoglobin in the blood, which is necessary to transport oxygen from the lungs to tissues and remove carbon dioxide from the body. If the process of erythropoiesis is disrupted, it can lead to various diseases such as anemia, leukemia and others.