Frelich's Disease

Froelich's disease is a rare disease characterized by dysfunction of the pituitary gland. Named after the Austrian neuropathologist and pharmacologist Adolf Fröhlich (1871-1953), who first described this disease in 1911.

In Froelich's disease, the pituitary gland becomes swollen, resulting in disruption of hormone production. This leads to delayed sexual development and obesity. Typical symptoms are excess weight with normal or even decreased appetite, amenorrhea in girls, and lack of puberty.

Treatment for Frohlich's disease includes surgical removal of the pituitary tumor and hormone replacement therapy to restore the endocrine system. With timely treatment, the prognosis is favorable.

Friedlich syndrome or Fröhlich disease is a rare autosomal recessive multisystem disorder characterized by acute onset, severe life-threatening respiratory failure in early childhood, and early damage to the heart, renal arteries, eyes, and nervous system. Later observations often reveal damage to the liver and other organs.

Fröhlich syndrome typically presents with jaundice, hepatosplenomegaly, and hypertension between 5 and 6 years of age and may precede the onset of respiratory symptoms and usually has an acute onset and is often called hyperacute synovitis. Renal failure in Frohlich syndrome can lead to the development of glomerulonephritis. Increased pressure in the carotid artery leads to meningioma of the brain - the so-called "Larrab Syndrome". Thromboembolic events (pulmonary embolus, infarction) often occur within 1 month after the acute onset of the disease.