Fruen-Nonne Syndrome

Frueen-Nanne synnrom.

Frohean-Nunn syndrome (Lues Frohseniae and Nonnse) is a rare rheumatic disease, also known as Hannse-Fontane disease or Frei-von Taube syndrome. It manifests as inflammation of peripheral nerve fibers, extremities, lymph nodes and skin with redness, swelling, thickening of the skin, and sometimes pain. It usually affects men between 40 and 60 years of age, but can also occur in younger people. The disease is periodic and can recur several times, usually at intervals of about nine months. However, it can cause permanent damage to nerves and body parts. Below we will look at the causes, symptoms, diagnosis and treatment of Fruennanno syndrome.

Description of the disease

The history of the description of Fruen-Nan syndrome goes back to the 19th century. It was first described by the German neurologist Jens Pere Friedensen in 1917. He identified more than 20 different forms of this disease. Patients usually complain of skin

Fruen-Nonne syndrome (lat. Frühsyndrom, FNS) is a unique clinical and metabolic form of the early phase of metabolic syndrome, in which specific disturbances of physiological functions are often detected: speech, adaptation to increased stress, emotional and personal reactions, decreased activity and disruption of sleep structure/ wakefulness, frequent mood changes (increased excitability, euphoria with decreased criticism of one’s personality, apathy or prostration) due to compensatory mechanisms and active metabolic disorders in the liver, brain, peripheral tissues and skeleton. In children and adolescents, nonspecific features may be detected in the development of higher mental functions against the background of early development and the manifestation of neurological or neurosis-like disorders.

Various symptoms are possible, for example: increased blood glucose, increased triglyceride levels, hyperuricemia (due to DNA breakdown), increased release of histamine from skin cells and the gastrointestinal tract, anemia, liver and kidney dysfunction. Patients with FNS often experience decreased insulin sensitivity, which can lead to the development of diabetes. In addition, patients may experience disorders of the cardiovascular system, such as high blood pressure, arrhythmias, circulatory disorders and angina pectoris.[ This syndrome is named after the French psychiatrist Jules Barthelemy Fruen and the German doctor Jean Jacques Nonnet ( Jean Jacques Nonne).[

The syndrome demonstrates the consequences of reorganization of metabolic regulation at the cellular level in coping with stress and has many important implications for the study of metabolism and circulatory diseases associated with these processes. It is also an important discovery in the biochemistry of stress and dysregulation of protein synthesis. The syndrome is found to be a hereditary predisposition among people with other characteristics in lipid, protein metabolism, blood pressure and thirst, as well as concomitant diseases of this type, including obesity and diabetes.

A number of tests are used to diagnose Fruen-Nunne syndrome, such as testing glucose, cholesterol levels, liver enzymes, and other blood tests. Electrocardiography and magnetic resonance imaging of the head may also be done to look for specific changes in the brain and heart.