Gliosarcoma

Gliosarcoma is a rare malignant brain tumor that combines features of glioma and sarcoma.

Gliosarcoma is a glial tumor of the brain. It is characterized by the presence of two components: glial (glioma-like) and sarcomatous (sarcoma-like).

The glial component is represented by astrocytic cells that form tumor fields. The sarcomatous component consists of spindle-shaped and pleomorphic cells forming bundles and crossbars.

Gliosarcoma is most often localized in the cerebral hemispheres, less often in the cerebellum or brain stem. The tumor can spread beyond the brain to the bones of the skull.

Clinical manifestations of gliosarcoma are similar to those of other brain tumors and include headaches, nausea, vomiting, visual disturbances, and limb weakness.

Diagnosis of gliosarcoma is based on CT, MRI and histological examination. Treatment includes surgical removal of the tumor, radiation therapy, and chemotherapy.

The prognosis for gliosarcoma is generally unfavorable. The average life expectancy after diagnosis is about 1 year. However, the prognosis depends on the location, size of the tumor and the possibility of its complete surgical removal.