Glutaminase

Glutamic acid (GABA) plays an important role in the mammalian nervous system. It is one of the main components of neurotransmitters in the central nervous system, including glutamate and aspartate. GABA is a neurotransmitter that plays a key role in regulating the level of excitation and inhibition in nerve cells. GABA is also a major precursor for the synthesis of other neurotransmitters such as glycine and serotonin.

However, excess GABA can be toxic to cells, which can lead to the development of various diseases, including epilepsy, Alzheimer's disease and other pathologies. To combat excess GABA, the enzyme glutamine oxidase was developed, which breaks down glutamic acid. This enzyme plays an important role not only in the treatment of these diseases, but also in the production of a number of drugs, such as lithium gluconate.

There are several types of glutamine oxidases, the most common of which is glutaminyl cyclase. It breaks down excess glutamic acid by oxidation with oxygen, forming GBA (gamma-aminobutyric acid). Glutamic acid is then completely deactivated within a few seconds. The compounds formed in this way effectively