Megakaryocytopathy

Megakaryocytopathy (megacaryocytopathia) is a pathological condition characterized by impaired function and development of megakaryocytes.

Megakaryocytes are large bone marrow cells responsible for the formation of platelets (blood platelets). With megakaryocytopathy, the maturation, differentiation and proliferation of megakaryocytes is impaired, which leads to a decrease in the number of platelets in the blood (thrombocytopenia).

The causes of megakaryocytopathy can be different:

1. congenital and hereditary diseases (for example, Bernard-Soulier syndrome);
2. acquired bone marrow diseases;
3. myelodysplastic syndrome;
4. leukemia;
5. taking certain medications.

Clinically, megakaryocytopathy is manifested by bleeding associated with thrombocytopenia. For diagnosis, a general and biochemical blood test, myelogram, and bone marrow trepanobiopsy are performed. Treatment depends on the cause of the disease and is aimed at restoring normal hematopoiesis.

**Megakaryocytopenia** is a rare blood disorder characterized by a decrease in the number of giant cells called megakaryocytes in the peripheral blood

The syndrome of “megakaryocytes in space” is detected in the form of finger-shaped atresia, granulosa bodies in the lungs, the formation of conglomerates, infarction