Minoxidil (Minoxidit)

Minoxidil is a drug used to treat high blood pressure when other medications have not responded. It is used in tablets along with diuretics, and also as a cream applied directly to the scalp to stimulate hair growth in people without hair loss. However, as with any medicine, the use of Minoxidil requires caution, especially when interacting with other medicines that may reduce the effectiveness of Minoxidil.

Minoxidil is a drug belonging to the group of peripheral vasolytics and antihypertensive agents. The main effect of which is to open calcium channels, which improves blood circulation in the peripheral vessels (arterioles) of the hair follicles on the scalp (androgen-dependent) and skin (its antiandrogenic form), as well as to increase the supply of oxygen to the hair follicle area. In addition, the drug has a high vasodilator effect on the smooth muscles of the blood vessels of the scalp, which determines its ability to reduce excess production of dihydrotestosterone in skin cells, etc. The action is based on the conversion of minoxidil into nitrogen monoxide NO and its further transport to the area of ​​the vascular walls, stimulating the production of the cyclic adenosine monophosphate system (cAMP) in vascular cardiomyocytes, which leads to the expansion of their lumen and an increase in the volume of blood flow, accordingly, oxygen supply to the hair follicles improves. After oral use, the drug breaks down into its active form - minoxidil. After penetration through the placental barrier, minoxidil is able to reach the secretory parts of the mammary glands in pregnant women, but its concentration in milk is insignificant (less than 0.1%) compared to the concentration of minoxidil after internal use (about 5-9% when taking 5-20 mg of the drug per day every day 4 weeks before birth and throughout the entire period of breastfeeding). Minoxidil is found in minimal amounts in urine during lactation. The Belgian Ministry of Health recommends not applying minoxidil to the skin above the eyebrows, as this area is most susceptible to cardiovascular disease. In addition, when taken in parallel with drugs that reduce heart rate (for example, beta blockers), a decrease in heart rate may occur. If co-administration with Minoxidil is necessary, it is necessary to monitor the patient's pulse and blood pressure.

**Minoxidil** is an active substance that is used to treat high blood pressure or hypertension when other medications are not effective. It can be taken orally or applied to the scalp and used to restore hair growth in men and women with pattern baldness.

**Description** Minroxidine is a drug from the group of peripheral vasodilators. The drug is used primarily in neurological practice to normalize the tone of the vascular system in encephalopathy and atherosclerosis. The active component of the drug significantly dilates blood vessels, improves blood flow and tissue metabolism. The medication is indicated for patients with neurocirculatory dystonia, stroke, dyscirculatory encephalopia, Raynaud's disease, etc.

In dermatology, it is used to reduce hair mass in androgenetic alopecia. Saturating the hair follicle with the bloodstream allows you to tone it, restore the cells of the follicles and hair follicles, as well as stimulate the growth activity of each hair and consolidate the resulting effect.

Another option for prescribing the medication is to suppress sebum production and normalize the growth of gray and white hair. But it is worth remembering that the drug in this situation can also provoke darkening of existing hair. It has many positive aspects, but is not without negative ones.

In pharmacology, there are a number of synonyms for the drug and an international nonproprietary name. Their dosage and method of administration may vary. The most famous trade names belong to the category of drugs: Lopatiten, Minaxidil, Minolax, Trenumal, Rxamine and others.

**Side effects**

Possible side effects of taking the drug include: - dizziness, - nausea, - rapid pulse, - ECG changes, as well as swelling, which disappear after stopping the drug and are more likely to be short-term effects. Minoxidil contains the active ingredient dihydroxyamine (305.14 mcg). The advantage of oral administration of the drug is the improvement of the condition and structure of the nails. Vessels that were previously clogged due to poor circulation begin to be fully supplied with oxygen. An important feature of the drug is its ability to affect the problem of reducing the concentration of testosterone in the blood. Increased estrogen levels in menopausal women reduce hair volume and promote hair loss. And the male gene pool stops the aging process and the manifestation of andropause symptoms. Both of these conditions can be treated with medication that helps the hair follicle regenerate and maintain normal hair growth.

However, like any other medicine, Minoxidil may cause side effects such as headache, dizziness, nausea and rapid heartbeat. In rare cases, changes in the electrocardiogram (ECG) and short-term swelling may occur. In general, the drug is considered safe when used correctly and in accordance with the dosage.

Minoxidil is a unique drug that is widely used to treat high blood pressure. This drug was developed over 50 years ago, but its use has continued unabated over time. It is known by various trade names, including lonitene and regaine.

Minoxidil is a peripheral va