Propofol 1% Fresenius

Propofol 1% Fresenius: description, application and features

Propofol 1% Fresenius is a drug that is used for non-inhalation anesthesia and sedation during mechanical ventilation. Propofol is a non-barbiturate drug that is quickly introduced into the body and also quickly eliminated from it.

Propofol is available as an emulsion for intravenous administration 1% and an emulsion for injection 1%. The drug is manufactured by Fresenius Kabi Austria GmbH in Austria.

The active ingredient of the drug is propofol. Propofol has a powerful sedative, anesthetic and anticonvulsant effect. It blocks the functioning of the nervous system, causing depression of the central nervous system, which leads to deep anesthesia.

Propofol is used for induction and maintenance of anesthesia, as well as for sedation during mechanical ventilation. It is used as an alternative to barbiturates in anesthesia because it has a shorter duration of action and fewer side effects.

Contraindications to the use of propofol include hypersensitivity to the drug. Restrictions on use include early childhood (under 3 years) and breastfeeding (breastfeeding should be discontinued).

Propofol can cause short-term respiratory arrest, shortness of breath, as well as rare side effects such as convulsions, opisthotonos, pulmonary edema. During awakening, headache, nausea, vomiting and postoperative fever may occur.

Propofol is compatible with drugs for spinal and epidural anesthesia, drugs used for premedication, muscle relaxants and analgesics.

In cases where there is a possibility of developing side effects associated with activation of the vagus nerve, it is advisable to administer an anticholinergic intravenously before induction of anesthesia. Propofol should not be used in obstetric practice, as it penetrates the placental barrier and can cause neonatal depression. However, it is possible to use the drug in the first trimester during abortion operations.

The risk of pain along the vein can be significantly reduced when infusions are administered through large-diameter veins or with the simultaneous administration of lidocaine solution. Propofol injections should be administered slowly while monitoring blood pressure and heart rate.

Propofol is a drug that can only be used in medical settings under the supervision of an experienced anesthesiologist. When using the drug, it is necessary to observe all safety measures and monitor the patient’s vital functions, such as blood pressure, heart rate and oxygen saturation.

In general, propofol 1% Fresenius is an effective drug for induction and maintenance of anesthesia, as well as for sedation during mechanical ventilation. However, its use should only be under the supervision of experienced medical personnel in accordance with medical care and safety protocols.