Protein Plasma Replacers

Replacement therapy is a treatment method that involves replacing missing or lost functions of organs and tissues through the use of drugs and biological agents.

Replacement therapy is one of the main methods of treatment for patients with chronic renal failure. With this pathology, there is a gradual decrease in the filtration function of the kidneys, which leads to the accumulation of nitrogen metabolism products in the blood and the development of uremic intoxication.

Various drugs are used as replacement therapy, such as:

– ACE inhibitors are angiotensin-converting enzyme blockers that reduce the level of angiotensin II and reduce the load on the kidneys.
– Angiotensin receptor antagonists are drugs that block angiotensin receptors, which also reduces the load on the kidneys and reduces the level of angiotensin.
– Diuretics are diuretics that remove excess fluid from the body, which also reduces the load on the kidneys.

In addition, plasma protein substitutes, which are drugs used for parenteral nutrition, are used to treat patients with uremic intoxication. They contain proteins necessary to maintain normal functioning of the body.

Protein plasma substitutes include:

  1. Hydrolysine is a drug containing amino acids that are necessary for the synthesis of proteins in the body. It is used for protein deficiency and when it is impossible to eat by mouth.
  2. Casein hydrolyzate is a product based on milk proteins, which also contains essential amino acids. It is used in the treatment of patients with acute protein deficiency and as a source of protein for parenteral nutrition.
  3. Aminopeptides are preparations based on amino acids, which also contain amino acids necessary for the body. They are used for parenteral nutrition and for the treatment of protein deficiency.
  4. Aminocrovin is a drug obtained from the blood of cattle, containing a large amount of amino acids.


Protein plasma substitutes are medications that are used for parenteral feeding of protein deficiency or nutrition of the body through injections. The most popular among them are hydrolysis mixture, whey protein and amino acids. Scientists have developed a special group of protein substitutes that are closer in structure to plasma protein. They help to compensate for the lack of nutrients in the body, to relieve the condition developed due to a lack of proteins in foods.