Tumor transplantation Isological

Tumor transplantation. Tumor cell transplantation is the process of introducing pre-cultured tumor cells into the patient's body in order to obtain the effect of hypercellular infiltration. Transplantation is carried out either inside the body (for example, during an ectopic pregnancy), or from outside the recipient’s organs and tissues (in order to prevent tissue reactions after reconstructive surgery). There are two fundamentally different approaches to this treatment - transplantation of cells from one person to another (so-called autotransplotation) and from a livestock-compatible donor or cellular material (allotransplotation, xenotransplotation).

Genetic recombinations during the process of transplotation. Cases have been described in which not only isolated donor cells penetrated the recipient's body, but also genetic fragments penetrated through diffusion into its genome. This was observed mainly in patients who received allogeneic fibroblasts, whose tissue contains mitochondria and some other bacteria. In a number of studies, this phenomenon was referred to as translocation (insertion of fragments of a foreign genome into the recipient's genes). It turned out that translocations occur mainly in rapidly dividing cells - embryonic fibroblasts and tissues,

What is tumor transplantation?

Tumor transplantation is a procedure to transplant cells or tissue from one organism to another. Sometimes this happens as part of an operation to treat cancer, as well as for experimental purposes. The operation is aimed at activating the immune response mechanisms to fight the tumor and cure the patient.

But transplantation is not only used to treat cancer. For example, a bone marrow transplant helps restore immunity after chemotherapy or a serious illness. The advantage of this method is the ability to achieve restoration of bone marrow function in a short time, usually within six months after starting the therapy program. It is important to note that the idea of ​​a bone marrow transplant is not only to restore immunity. The fact is that this organ also contains cells of various tissues and organs, which provide the patient with new functional capabilities and solve other problems of his health.

Transpanion of the tumor and a healthy donor organ are components in the “healthy-sick” system. The most important is the histogenetic similarity between the tumor and the donor, as well as the isology of the blood group. In transplantation, immunological identity is considered incompatible when there is no donor and recipient and there is no rejection to the recipient. Isolation from the same blood type virtually eliminates graft-versus-host disease in the donor. In such cases, the operation successfully accomplishes its goal.