Vero-Clarithromycin

Country of origin - Russia
Pharm-Group - Antibiotics - macrolides and azalides

Manufacturers - Veropharm/Belgorod branch (Russia)
International name - Clarithromycin
Synonyms - Binoklar, Klabaks, Klarbakt, Clarithromycin Protekh, Clarithromycin-Verte, Clarithrosin, Klacid, Klacid SR, Clerimed, Fromilid, Fromilid uno
Dosage forms - film-coated tablets 250 mg

Composition - Active substance - Clarithromycin.

Indications for use - Infections of the upper respiratory tract and ENT organs (tonsillopharyngitis, otitis media, acute sinusitis), lower respiratory tract (acute bronchitis, exacerbation of chronic bronchitis, bacterial and atypical pneumonia), skin and soft tissues, mycobacterial infection (M.avium complex, M.cansasii, M.marinom, M.leprae), peptic ulcer of the duodenum and stomach caused by Helicobacter pylori (combination therapy).

Contraindications - Hypersensitivity, severe liver disease, porphyria, pregnancy and breastfeeding.

Side effects - Nausea, vomiting, taste change, abdominal pain, diarrhea, pseudomembranous colitis, stomatitis, glossitis, dizziness, headache, anxiety, fear, insomnia, nightmares, increased activity of liver enzymes, cholestatic jaundice, allergic (urticaria, Stevens-Johnson syndrome, etc.) and anaphylactoid reactions.

Interaction - Increases the concentration in the blood of drugs metabolized in the liver with the participation of enzymes of the cytochrome P450 complex: warfarin and other indirect anticoagulants, carbamazepine, theophylline, astemizole, cisapride, thiazolam, midazolam, cyclosporine, digoxin, ergot alkaloids, etc., reduces the absorption of zidovudine.

Overdose - Symptoms: nausea, vomiting, diarrhea. Treatment: gastric lavage, symptomatic therapy. Hemodialysis and peritoneal dialysis are ineffective.

Special instructions - Prescribe with caution against drugs metabolized by the liver (it is recommended to measure their concentration in the blood). In case of combination with warfarin or other indirect anticoagulants, it is necessary to monitor the prothrombin time. If you have a history of heart disease, simultaneous use with terfenadine, cisapride, or astemizole is not recommended.

Literature - Encyclopedia of Medicines 2003.