The gastric field is a segment of the surface of the stomach that has a unique topographic pattern with a varying number of folds and chemosensory areas. Each gastric field has its own specific motor and secretory activity, which may explain a variety of clinical manifestations in the gastrointestinal (GI) tract, including esophageal diseases, gastroesophageal reflux, acid reflux and peptic ulcers. Research shows a connection between rigid stomach linings and acid reflux. However, healthy gastric fields may also have imbalances in the regulation of motility and secretion, especially in patients with gastrointestinal diseases. In this article, we review the history and current knowledge of gastric fields, their relationship with health and disease, including clinical significance and clinical recommendations for the diagnosis, therapy, and prevention of gastrointestinal diseases.