Blood-lymphatic Barrier

The hepatolymphatic (hepatovascular) barrier is the boundary between the blood and surrounding tissues, which does not allow macromolecules to pass back into the blood. This means that all substances pass through the barrier in only one direction - from the extracellular fluid towards the bloodstream.

The barrier consists of body cells such as endothelium, pericytes and leukocytes, which limit the exchange of substances in the space between the blood capillaries and the intercellular space. When neutrophil granulocytes migrate into a pathological state, they become more active, releasing toxic substances that can damage cells and tissues.

Due to the structure, formation and functioning of the hemolymphatic barrier, the mechanisms of cell division and receptor processes function in parallel and mutually. However, in some cases the barrier does not work properly, leading to severe diseases such as cirrhosis of the liver, malignancies and infections.