Suction Coefficient Real

The real absorption coefficient (RAC) is an indicator characterizing the degree of absorption of a substance in the gastrointestinal tract, taking into account its possible release back into the intestinal lumen.

K.v.r. determined during pharmacokinetic studies using radioactively labeled compounds. This takes into account not only the amount of radioactivity that enters the bloodstream after taking the drug orally, but also the release of radioactive metabolites into the intestinal lumen.

Thus, K.v.r. gives a more accurate estimate of the extent of absorption of a substance compared to the apparent absorption coefficient, which is calculated only on the basis of the concentration of the substance in the blood, without taking into account its possible loss in the gastrointestinal tract.

K.v.r. is an important pharmacokinetic parameter that allows optimizing dosage forms for maximum absorption of the active substance.

Real suction coefficient - K.v.r. used in dosimetry to determine radiosensitivity and predict the effects of ionizing radiation on the body. Measurement of radioactivity of biological materials is based on the properties of natural radioactivity: radioactive decay of atoms; the ability of radioactive isotopes to emit electrons or other particles.

The real absorption coefficient is a parameter that reflects the amount of nutrients absorbed by the body. It is calculated by dividing the mass of food taken by its volume. This indicator may vary depending on the individual characteristics of the person, such as age, gender, physical activity and type of diet.

The absorption coefficient (AC) is an indicator that reflects the amount of absorbed radioactive isotope entering the blood and its subsequent absorption through the wall of the gastrointestinal tract. This indicator is of great importance when studying the bioavailability of drugs and the safety of their use from the point of view of toxicity.

One of the most common methods for determining the absorption coefficient is a test with radioinduced exchange plasma. This method involves injecting several doses of radioactively labeled substances into the stomach and then collecting plasma from the animal's blood, which is then mixed with samples of an unknown dose size. Thus, knowing the amount of radioactivity accumulated in the plasma, it is possible to determine what percentage of the dose was absorbed by the animal.

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