Acetene

Country of origin - India
Pharm-Group - Antihypertensives - angiotensin-converting enzyme inhibitors

Manufacturers - Wockhard Limited (India)
International name - Captopril
Synonyms - Alkadil, Angiopril, Angiopril-25, Apo-Capto, Blockordil, Vero-Captopril, Gen-Captopril, Capocard, Capoten, Capofarm, Capril, Capto, Captopril, Captopril 25, Captopril Hexal, Captopril OF, Captopril Stada International, Captopril -Akos, Captopril-Acri, Capt
Dosage forms - tablets 25 mg
Composition - Active ingredient - Captopril.

Indications for use - Arterial hypertension (mono- and combination therapy), congestive heart failure, cardiomyopathy, impaired left ventricular function in a stable condition in patients after myocardial infarction, diabetic nephropathy against the background of type 1 diabetes mellitus.

Contraindications - Hypersensitivity, the presence of anamnestic information about the development of Quincke's edema with previous prescription of ACE inhibitors, hereditary or idiopathic Quincke's edema, primary hyperaldosteronism, pregnancy, breastfeeding. Restrictions on use: An assessment of the risk-benefit ratio is necessary in the following cases: leukopenia, thrombocytopenia, aortic stenosis or other obstructive changes that impede the outflow of blood from the heart; hypertrophic cardiomyopathy with low cardiac output; severe renal dysfunction; bilateral renal artery stenosis or stenosis of the artery of a single kidney; presence of a transplanted kidney; hyperkalemia; childhood.

Side effects - From the nervous system and sensory organs: fatigue, dizziness, headache, central nervous system depression, drowsiness, confusion, depression, ataxia, convulsions, numbness or tingling sensation in the extremities, visual impairment and/or smell. From the cardiovascular system and blood (hematopoiesis, hemostasis): hypotension, incl. orthostatic, angina pectoris, myocardial infarction, cardiac arrhythmia (atrial tachy- or bradycardia, atrial fibrillation), palpitations, acute cerebrovascular accident, peripheral edema, lymphadenopathy, anemia, chest pain, pulmonary embolism, neutropenia, agranulocytosis (in patients with impaired renal function, against the background of collagenosis), thrombocytopenia, eosinophilia. From the respiratory system: bronchospasm, shortness of breath, interstitial pneumonitis, bronchitis, non-productive dry cough. From the gastrointestinal tract: anorexia, taste disturbance, stomatitis, ulcerative lesions of the oral and gastric mucosa, xerostomia, glossitis, difficulty swallowing, nausea, vomiting, dyspepsia, flatulence, abdominal pain, constipation or diarrhea, pancreatitis, liver damage (cholestasis , cholestatic hepatitis, hepatocellular necrosis). From the genitourinary system: impaired renal function, oliguria, proteinuria, impotence. From the skin: redness of the facial skin, rash, itching, exfoliative dermatitis, toxic epidermal necrolysis, pemphigus, herpes zoster, alopecia, photodermatitis. Allergic reactions: Stevens-Johnson syndrome, urticaria, Quincke's edema, anaphylactic shock, etc. Others: fever, chills, sepsis, arthralgia, hyperkalemia, gynecomastia, serum sickness, increased blood levels of liver enzymes, urea nitrogen, acidosis, positive reaction when testing for antibodies to nuclear antigen.

Interaction - Potentiates the hypoglycemic effect of oral antidiabetic drugs, enhances the possible hypotensive effect of anesthetics. Reduces secondary hyperaldosteronism and hypokalemia caused by diuretics. Increases plasma concentrations of lithium and digoxin. The effects are enhanced by other hypotheses