Adenocytes Eosinophilic

Cells of the adenohistiocytic series Eo-ASC (eosionophilic adenocytes) - belong to a diverse group of cells of the macrophage-histiotrophic type (according to Michaelis), characterized by a high level of synthesis and activity of various isoforms of histamine, as well as phgolithin. They are part of the reactive tissue of the lungs, endocardium, gastrointestinal tract and mesenchymal elements in mammals. They produce large numbers of eosinophils and are involved in the production of pro-inflammatory cytokines, such as IL-12 and TNF-alpha, which contribute to the development and maintenance of the inflammatory response in allergies, infections and autoimmune diseases. In particular, they are one of the key factors in the mechanisms of type 2 hypersensitivity (H2), such as bronchial asthma, atopic dermatitis, food allergy and allergic rhinitis.

Some members of the EASC group are defined as osteocyte-like or osteogenic subtypes of macrophages with increased expression of certain smooth muscle cell markers, including cluster of differentiation 90A, Chemocaine type, and transforming growth factor beta, the expression of which suggests their parahormonal function.

Many type 3 macrophages, such as brain microglia, are involved in embryonic development, tissue repair, maintenance of homeostasis, and other physiological processes. Although these diseases appear to differ in etiology and pathogenesis, their manifestations in some cases include the formation of eosinophilic granules in the cytoplasm of their specific