Akkupro

Country of origin - Germany, Goedecke/Parke-Davis Germany

Pharm-Group - Antihypertensives - angiotensin-converting enzyme inhibitors

Manufacturers - Goedecke GmbH (Germany), Goedecke/Parke-Davis (Germany)

International name - Quinapril

Dosage forms - film-coated tablets 5mg, 10mg, 20mg

Composition - Active substance - quinapril

Indications for use - Arterial hypertension, chronic heart failure

Contraindications - Hypersensitivity, angioedema, renal artery stenosis, mitral valve disease, hypertrophic myocardiopathy, primary hyperaldosteronism, severe renal dysfunction (creatinine clearance less than 30 ml/min), condition after kidney transplantation, severe heart failure in the decompensation phase, pregnancy, lactation breastfeeding (stopped during treatment), childhood and adolescence (up to 14 years)

Side effects - Arterial hypotension, tachycardia, rhythm disturbances, myocardial ischemia, ischemic stroke, deterioration of peripheral circulation, dizziness, weakness, blurred vision, proteinuria, acute renal failure, dry cough, bronchitis, sinusitis, bronchospasm, myalgia, arthralgia, transient thrombocytopenia, leukopenia, oliguria, increased concentrations of creatinine and urea in the blood plasma, photosensitivity, skin rash, itching

Interaction - When prescribed together with other antihypertensive drugs - an additive effect, with potassium-sparing diuretics - hyperkalemia, with lithium - increased lithium toxicity, with antacids - increased absorption. Allopurinol, procainamide, cystostatics and glucocorticoids increase leukopenia, and NSAIDs, opioid analgesics, hypnotics and general anesthetics increase the hypotensive effect. Absorption is reduced by tetracycline antibiotics and enhances the effect of alcohol.

Overdose - No data available

Special instructions - It is recommended to use only in a hospital setting. Prescribe with caution to patients with immunopathological and depressive conditions. 2-3 days before the start of the course, diuretics should be discontinued and the water and electrolyte balance should be adjusted. Careful monitoring of blood pressure is necessary, especially in patients over 65 years of age. For patients with severe renal impairment, the dose is halved. During therapy, alcohol intake is excluded.

Literature:

1. Register of Medicines 2001.