Aklotin

Country of origin - Poland
Pharm group - Antiplatelet agents

Manufacturers - ICN Polfa Rzeszow (Poland)
International name - Ticlopidine
Synonyms - Tagren, Tiklid, Tiklo
Dosage forms - film-coated tablets 250 mg
Composition - active substance - ticlopidine

Indications for use:

  1. Acute myocardial infarction
  2. Unstable angina
  3. Transient cerebrovascular accidents
  4. Conditions after heart valve replacement, coronary artery bypass surgery and angioplasty
  5. Severe atherosclerosis of peripheral arteries
  6. Intermittent claudication
  7. Chronic glomerulonephritis
  8. Sickle cell anemia
  9. Microangiopathy in diabetes mellitus

Contraindications:

  1. Hypersensitivity
  2. Acute peptic ulcers of the stomach
  3. Danger of bleeding during exacerbation of gastric and duodenal ulcers
  4. Intracranial hemorrhage
  5. Hemorrhagic diathesis
  6. Neutropenia, thrombocytopenia
  7. Severe liver dysfunction
  8. Acute stroke
  9. Pregnancy, lactation

Side effect:

  1. Gastrointestinal disorders, less often - bleeding, hemorrhagic rashes, hematuria
  2. Thrombocytopenia, neutropenia, severe agranulocytosis, pancytopenia
  3. Dizziness, headache, tinnitus, asthenia
  4. Increased levels of cholesterol and triglycerides in the blood serum, increased activity of transaminases and alkaline phosphatase, cholestatic jaundice
  5. Rash, itching

Interaction:

  1. Increases the inhibitory effect of aspirin and other NSAIDs on platelet aggregation and increases the risk of bleeding
  2. Antacids, by reducing absorption, reduce plasma concentrations by 18%
  3. Cimetidine reduces the clearance of ticlopidine by 50%, reduces the level of digoxin in the blood by 15%, and the clearance of theophylline
  4. Increases plasma concentrations of phenytoin

Overdose:

  1. Hemorrhagic syndrome, convulsions, hypothermia, shortness of breath, vestibular disorders
  2. Treatment: Call an ambulance immediately

Special instructions:

  1. Limited use for injuries, planned surgical operations, in childhood
  2. During treatment, it is desirable to control the cellular composition of peripheral blood and the state of the coagulation system

Literature:

  1. Register of Medicines of Russia 2002
  2. Griffith "Newest Medicines" vol. 2 p. 386