Country of origin - Poland
Pharm group - Antiplatelet agents
Manufacturers - ICN Polfa Rzeszow (Poland)
International name - Ticlopidine
Synonyms - Tagren, Tiklid, Tiklo
Dosage forms - film-coated tablets 250 mg
Composition - active substance - ticlopidine
Indications for use:
- Acute myocardial infarction
- Unstable angina
- Transient cerebrovascular accidents
- Conditions after heart valve replacement, coronary artery bypass surgery and angioplasty
- Severe atherosclerosis of peripheral arteries
- Intermittent claudication
- Chronic glomerulonephritis
- Sickle cell anemia
- Microangiopathy in diabetes mellitus
Contraindications:
- Hypersensitivity
- Acute peptic ulcers of the stomach
- Danger of bleeding during exacerbation of gastric and duodenal ulcers
- Intracranial hemorrhage
- Hemorrhagic diathesis
- Neutropenia, thrombocytopenia
- Severe liver dysfunction
- Acute stroke
- Pregnancy, lactation
Side effect:
- Gastrointestinal disorders, less often - bleeding, hemorrhagic rashes, hematuria
- Thrombocytopenia, neutropenia, severe agranulocytosis, pancytopenia
- Dizziness, headache, tinnitus, asthenia
- Increased levels of cholesterol and triglycerides in the blood serum, increased activity of transaminases and alkaline phosphatase, cholestatic jaundice
- Rash, itching
Interaction:
- Increases the inhibitory effect of aspirin and other NSAIDs on platelet aggregation and increases the risk of bleeding
- Antacids, by reducing absorption, reduce plasma concentrations by 18%
- Cimetidine reduces the clearance of ticlopidine by 50%, reduces the level of digoxin in the blood by 15%, and the clearance of theophylline
- Increases plasma concentrations of phenytoin
Overdose:
- Hemorrhagic syndrome, convulsions, hypothermia, shortness of breath, vestibular disorders
- Treatment: Call an ambulance immediately
Special instructions:
- Limited use for injuries, planned surgical operations, in childhood
- During treatment, it is desirable to control the cellular composition of peripheral blood and the state of the coagulation system
Literature:
- Register of Medicines of Russia 2002
- Griffith "Newest Medicines" vol. 2 p. 386