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Country of origin - France
Pharm-Group - Anti-inflammatory drugs - propionic acid derivatives

Manufacturers - Roche-Nicolas Laboratory (France)
International name - Naproxen
Synonyms - Apo-Naproxen, Apranax, Aprol, Daprox entero, Inaprol, Naxen, Nalgesin, Nalgesin forte, Nalixan, Naprios, Naprobene, Naproxen, Naproxen-ICN, Naproxen-Acri, Naproxen-Teva, Naproxen sodium salt, Naprosin, Noritis, Pronaxen, Sanaprox
Dosage forms - film-coated tablets 220 mg
Composition - Active ingredient - naproxen.
Indications for use - Rheumatism, rheumatoid arthritis, reactive synovitis with deforming osteoarthritis, ankylosing spondylitis, articular syndrome with exacerbation of gout, neuralgia, myalgia, migraine, toothache, adnexitis, primary dysmenorrhea, tumor, traumatic, postoperative pain, diseases of the ENT organs, febrile conditions.
Contraindications - Hypersensitivity, “aspirin” triad (asthma, rhinitis, recurrent nasal polyposis), other manifestations of intolerance to NSAIDs, peptic ulcer of the stomach and duodenum in the acute phase. Restrictions on use: Severe cardiac, hepatic and renal failure, hematopoietic disorders, adolescence (up to 16 years), pregnancy, breastfeeding (breastfeeding should be avoided).
Side effects - Heartburn, nausea, vomiting, epigastric discomfort, diarrhea, NSAID gastropathy (damage to the antrum of the stomach in the form of mucosal erythema, hemorrhages, erosions and ulcers), erosive and ulcerative lesions of other parts of the gastrointestinal tract, bleeding, eosinophilic pneumonia, headache pain, tinnitus, dizziness, weakness, sweating, drowsiness, slow reaction rate, hearing impairment, liver and kidney function, thrombocytopenia, granulocytopenia, aplastic anemia, allergic reactions (skin rashes, itching, Quincke's edema).
Interaction - Increases the toxicity of hydantoin, indirect anticoagulants, sulfonamides, methotrexate (blocks tubular secretion). Reduces the natriuretic and diuretic effect of furosemide, hypotension caused by beta blockers. Reduces the excretion of lithium salts and increases its concentration in plasma. Antacids containing magnesium and aluminum reduce absorption.
Overdose - Symptoms: drowsiness, heartburn, dyspepsia, nausea, vomiting. Treatment: gastric lavage, administration of activated carbon - 0.5 g/kg; dialysis is not effective.
Special instructions - With long-term use, it is necessary to monitor the functions of the liver and kidneys, the composition of peripheral blood. If it is necessary to determine 17-ketosteroids or 5-hydroxyindoleacetic acid, treatment should be discontinued 48 hours before the study.
Literature - Encyclopedia of Medicines 2003.