Aminophylline

Country of origin: Russia, Gedeon Richter A.O. Hungary, Krakow Pharmaceutical Plant Polfa Poland, Lek DD Slovenia, Polfa Poland, Remedica Ltd Cyprus, Far Ka Italy

Pharm-Group: Bronchodilators - phosphodiesterase inhibitors

Manufacturers: Borisov Medical Preparations Plant (Russia), Gedeon Richter A.O. (Hungary), Krakow Pharmaceutical Plant Polfa (Poland), Lek DD (Slovenia), Polfa (Poland), Remedica Ltd. (Cyprus), Far-Ka (Italy )

International name: Aminophylline

Synonyms: Aminomal, Diafillin gluteusum, Pharmafillin, Eufillin, Eufillin for injection

Dosage forms: solution for intravenous injection 240 mg, solution for injection 250 mg, solution for intravenous injection 2.5%, suppositories 360 mg, solution for injection 2.4%, retard tablets 350 mg

Composition: A mixture consisting of 80% theophylline and 20% ethylenediamine.

Indications for use: Chronic obstructive bronchitis, bronchial asthma, status asthmaticus (additional therapy), emphysema, neonatal apnea, Cheyne-Stokes respiration.

Contraindications: Hypersensitivity, acute gastritis, gastric and duodenal ulcers, arrhythmia, arterial hypertension, myocardial pathology, myocardial infarction, heart failure, prostate adenoma, diarrhea, fibrocystic mastopathy, alcoholism, cor pulmonale, fever, hypoxemia, infections respiratory tract, liver dysfunction, hyperthyroidism, chronic and acute renal failure, edema syndrome, hypernatremia, rectal diseases, lactation.

Side effects: Heartburn, vomiting, chest pain, palpitations, hypotension, headache, dizziness, flushing, tachypnea, allergic reactions (sweating, fever), reactions at the injection site.

Interaction: Increases the likelihood of developing side effects of glucocorticoids, mineralocorticoids, anesthetics, xanthines and central nervous system stimulants, beta-adrenergic agonists. Reduces the specific activity of lithium salts. Oral contraceptives (estrogen-containing), antidiarrheal drugs, intestinal sorbents weaken, and H2-histamine blockers, fluoroquinolones, calcium channel blockers, beta-blockers, mexiletine, erythromycin enhance the effect of aminophylline.

Overdose: Symptoms: nausea, vomiting, pain in the epigastric region, gastrointestinal bleeding, anorexia, diarrhea, tachypnea, facial flushing, tachycardia, ventricular arrhythmias, insomnia, anxiety, photophobia, generalized convulsions. Treatment: discontinuation of prep

Special instructions: No data available.

Literature: Encyclopedia of Medicines 2004