Amitriptyline-Akos

Country of origin - Russia
Pharm-Group - Antidepressants - non-selective inhibitors of neuronal uptake

Manufacturers - Sintez AKO, Kurgan (Russia)
International name - Amitriptyline
Synonyms - Amizol, Amineurin, Amiptyline, Amiton, Amitriptyline, Amitriptyline Lechiva, Amitriptyline Nycomed, Amitriptyline-Grindeks, Amitriptyline-LENS, Amitriptyline-Slovakofarma, Amitriptyline-Ferein, Amitriptyline hydrochloride, Apo-Amitriptyline, Vero-Amitripti Lin, Damile
Dosage forms - solution for injection 20 mg
Composition - Active substance - amitriptyline.
Indications for use: Depression, depressive syndrome, schizophrenic psychoses, anxiety-depressive states of various origins, mixed emotional disorders, behavioral disorders, psychogenic anorexia, nocturnal enuresis (auxiliary treatment), severe pain of a neurogenic nature.
Contraindications - Hypersensitivity, glaucoma, epilepsy, prostatic hyperplasia, bladder atony, paralytic ileus, history of myocardial infarction, use of MAO inhibitors in the previous 2 weeks, pregnancy, lactation, children (up to 6 years).

Side effect - Blockade of peripheral M-cholinergic receptors: dry mouth, urinary retention, constipation, blurred vision, accommodation, increased sweating. From the cardiovascular system: tachycardia, orthostatic hypotension, increased blood pressure, conduction disturbances. From the side of the central nervous system: drowsiness, dizziness, tremor. Allergic reactions: skin rash and others.

Interaction - Incompatible with MAO inhibitors. Enhances the effect of compounds that depress the central nervous system, sympathomimetics, antiparkinsonian drugs, weakens the effect of antihypertensive and anticonvulsant drugs. Barbiturates and carbamazepine reduce, and cimetidine increases plasma concentrations.

Overdose - Symptoms: hallucinations, convulsions, coma, cardiac conduction disturbances, extrasystole, gastric arrhythmias, hypothermia. Treatment: gastric lavage, taking an activated carbon suspension, laxatives, maintaining body temperature, monitoring the function of the cardiovascular system.

Special instructions - Should not be prescribed to manic patients and patients with suicidal tendencies. Use with caution for ischemic heart disease, arrhythmias, heart failure. During treatment, you should avoid drinking alcohol, as well as avoid activities that require increased attention and speed of reactions.

Literature - Encyclopedia of Medicines 9th edition 2002. Medicines M.D. Mashkovsky 14th edition, 2000.