Amlovas

Country of origin - India
Pharm-Group - Calcium channel blockers of the dihydropyridine group

Manufacturers - Unique Pharmaceutical Laboratories (India)
International name - Amlodipine
Synonyms - Agen, Acridipine, Amlodipine, Amlotop, Aronar, Vero-Amlodipine, Kalchek, Cardilopin, Corvadil, Norvadin, Norvasc, Normodipine, Omelar cardio, Stamlo, Tenox
Dosage forms - 5 mg tablets, 10 mg tablets
Composition - Active substance - Amlodipine.

Indications for use - Arterial hypertension, stable and vasospastic angina (Prinzmetal), including in patients resistant to therapy with nitrates or beta-blockers.

Contraindications - Hypersensitivity, arterial hypotension (less than 90 mm Hg), shock, acute myocardial infarction. Restrictions on use: severe aortic stenosis, heart failure, liver dysfunction, children's age (safety and effectiveness of use have not been determined).

Side effect -

1. From the cardiovascular system and blood: facial skin flushing, palpitations; rarely - rhythm disturbances, chest pain, hypotension (including orthostatic).
2. From the nervous system and sensory organs: fatigue, headache, dizziness, drowsiness; rarely - fatigue, asthenia, mood changes, visual disturbances.
3. From the genitourinary system: peripheral edema (swelling of the ankles and feet); rarely - increased frequency of urination, impotence.
4. From the gastrointestinal tract: nausea, abdominal pain; rarely - dyspepsia, change in bowel habits, jaundice.
5. From the respiratory system: rarely - shortness of breath.
6. From the musculoskeletal system: rarely - arthralgia, myalgia, paresthesia and pain in the extremities (with long-term use).
7. From the skin: rashes, itching, rarely - erythema multiforme.
8. Other: rarely - gingival hyperplasia, gynecomastia, increased levels of liver enzymes.

Interaction - Compatible with the main groups of antihypertensive drugs (diuretics, ACE inhibitors, beta-blockers), nitrates and hypoglycemic drugs. May enhance the effect: inhalation anesthetics (hydrocarbon derivatives), amiodarone, quinidine and other calcium antagonists (may enhance the effect). NSAIDs reduce the antihypertensive effect.

Overdose - Symptoms: excessive peripheral vasodilation, pronounced and prolonged decrease in blood pressure, tachycardia. Treatment: gastric lavage, administration of activated charcoal, placing the patient in a horizontal position with raised legs, monitoring ra

Special instructions - Use during pregnancy and breastfeeding is possible if the expected effect of therapy exceeds the potential risk to the fetus. Breastfeeding should be stopped during treatment.

Literature - Encyclopedia of Medicines 2002. Encyclopedia of Medicines 2003, Encyclopedia of Medicines 2003