Apo-Doxy

Apo-Doxy: uses, side effects and interactions with other drugs

Apo-Doxy is a drug containing the active substance doxycycline, which belongs to the group of tetracycline antibiotics. This drug is produced in Canada by Apotex Inc., as well as in Russia by Vector and Vector-Pharm. In this article we will look at the indications for use of Apo-Doxy, its side effects and interactions with other medications.

Indications for use of Apo-Doxy

Apo-Doxy is used to treat infections caused by various microorganisms. These include Haemophilus influenzae, chlamydia, mycoplasma, rickettsia, borrelia, brucella, yersinia, bacillary and amoebic dysentery, tularemia, cholera, Lyme disease, actinomycosis, malaria, leptospirosis, trachoma, psittacosis, granulocytic ehrlichiosis and other infectious diseases. Apo-Doxy is also used to treat diseases of the ENT organs and lower respiratory tract, urinary tract infections, urogenital mycoplasmosis, pelvic inflammatory diseases in women, acute prostatitis, gonorrhea, syphilis, purulent infections of the skin and soft tissues, acne, infectious ulcerative keratitis.

In addition, Apo-Doxy can be used to prevent surgical infections after medical abortion and colon surgery, as well as to prevent Plasmodium falciparum malaria during short-term travel to areas where Plasmodium resistance to chloroquine and/or pyrimethamine-sulfadoxine has been noted.

Side Effects of Apo-Doxy

Apo-Doxy may cause some side effects. Among them are dizziness, sweating, vascular collapse, benign intracranial hypertension in adults and protrusion of the fontanelles in children, nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dysphagia, glossitis, esophagitis, dysbacteriosis, fungal infections, reinfections with resistant strains, eosinophilia, neutropenia, photosensitivity, persistent discoloration of tooth enamel, allergic reactions such as urticaria, angioedema and anaphylactic shock.

In rare cases, with long-term use of Apo-Doxy, hepatitis, pancreatitis, interstitial nephritis, leukopenia, thrombocytopenia, hemolytic anemia, aseptic meningitis, increased levels of creatinine nitrogen in the blood, as well as a toxic effect on the liver, especially when combined with alcohol, may develop.

Interaction of Apo-Doxy with other drugs

Apo-Doxy may interact with other medications, which may increase or decrease their effectiveness or cause side effects. For example, when Apo-Doxy is used concomitantly with antiacids containing aluminum, magnesium, calcium and iron, the absorption of doxycycline may be reduced, resulting in a decrease in its effectiveness. The simultaneous use of Apo-Doxy with anticoagulants such as warfarin is also not recommended, as this may lead to an increase in blood clotting time.

When Apo-Doxy is used simultaneously with phenytoin, carbamazepine, barbiturates, rifampicin and some other drugs, active removal of doxycycline from the body may occur, which can also lead to a decrease in its effectiveness.

In general, before starting to use Apo-Doxy or any other drug, you should consult your doctor or pharmacist to determine whether there are any contraindications or interactions with other medications.