Aprotimbin

Aprotimbin: description, application and side effects

Aprothymbine, also known as aprotinin, is a proteolysis inhibitor that is used in medicine to treat various diseases. This drug was developed by Biochemi GmbH in Austria and has the international name Aprotinin. In this article we will look at the main characteristics of this drug, its use and side effects.

Characteristics of aprotimbin

Aprotimbin is a proteolysis inhibitor that is used to suppress the activity of proteases - enzymes that destroy proteins. The active substance of this drug is aprotinin, which is produced in the form of an injection solution with varying concentrations of the active substance.

Use of aprotimbin

Aprotimbin is used to treat the following diseases:

1. Pancreatitis (acute, exacerbation of chronic, postoperative prevention), pancreatic necrosis.
2. Hyperfibrinolytic bleeding - post-traumatic, postoperative (especially during operations on the prostate gland, lungs).
3. Before, during and after childbirth, complications of thrombolytic therapy, open heart surgery using artificial blood circulation machines, etc.
4. Treatment and prevention of various forms of shock (endotoxic, traumatic, hemolytic), postoperative mumps.

Contraindications and side effects

Aprotimbin is not recommended for use in case of hypersensitivity to the drug, disseminated intravascular coagulation syndrome, pregnancy (first trimester) and breastfeeding.

Side effects of aprothymbine may include hallucinations, confusion, psychosis, arterial hypotension, tachycardia, bronchospasm, allergic (skin rash) and anaphylactic (up to anaphylactic shock) reactions, with rapid administration - nausea, vomiting, with prolonged administration - thrombophlebitis at the injection site .

Aprothymbine interaction

Aprotimbin is pharmaceutically incompatible with other drugs, with the exception of solutions of electrolytes and glucose. It can also reduce the activity of fibrinolytic agents, including streptokinase and urokinase.

Special instructions for the use of aprotimbin

Before using aprotimbin, it is necessary to conduct a skin test to identify possible allergic reactions. The drug should be used only under the supervision of a physician, who should monitor blood clotting parameters and kidney function.

The dosage of aprotimbin depends on the specific disease and condition of the patient. The drug is usually administered intravenously, as an infusion or injection, at a dosage of 10,000 to 100,000 CAU (cell-acting units) per day.

In conclusion, aprothymbine is a potent proteolysis inhibitor that may be effective in the treatment of various diseases. However, before using this drug, you should consult a doctor and become familiar with possible side effects.