Artesin

Country of origin - Russia
Pharm-Group - Selective alpha1-blockers

Manufacturers - Shchelkovo Vitamin Plant (Russia)
International name - Doxazosin
Synonyms - Doxazosin, Doxazosin-Vero, Doxaprostan, Zoxon, Kamiren, Cardura, Cardura HL, Cardura, Magurol, Tonocardin
Dosage forms - 2 mg tablets, 4 mg tablets
Composition - Active substance - doxazosin.

Indications for use - Arterial hypertension, incl. isolated systolic hypertension in elderly men, hypertension associated with metabolic disorders, chronic heart failure, pheochromocytoma, benign prostatic hyperplasia, obstructed urine outflow.

Contraindications - Hypersensitivity, stenosis of the aortic and mitral valves, pulmonary embolism, severe liver dysfunction, pregnancy, childhood.

Side effect - The effect of the "first dose" - hypotension, dizziness, syncope (rarely); postural orthostatic hypotension, nervousness, irritability, pathological drowsiness, edema, tachycardia, rhythm disturbances, fatigue, shortness of breath, dizziness, headache, blurred vision, rhinitis, xerostomia, abdominal discomfort, nausea, constipation, chest pain, brain disorder blood circulation, urinary incontinence.

Interaction - Doxazosin enhances the hypotensive effect of antihypertensive drugs. NSAIDs, estrogens and sympathomimetics reduce the hypotensive effect. Reduces the pressor effect of ephedrine. When combined with inducers of microsomal oxidation in the liver, an increase in effect is possible, and with inhibitors - a decrease.

Overdose - Symptoms: hypotension, syncope. Treatment: it is necessary to place the patient in a horizontal position on the back, with the head at the level of the body; in case of ineffectiveness, intravenous infusions and the introduction of vasopressor drugs.

Special instructions - The effect of the first dose is especially pronounced against the background of diuretic therapy, as well as with a sodium-restricted diet. In older people, the dosage is reduced. The possibility of orthostatic hypotension should be taken into account, as well as a decrease in concentration and reaction speed when driving vehicles and working in production. Before starting therapy for benign prostatic hyperplasia, it is necessary to exclude its cancerous degeneration. Use with caution in case of liver dysfunction.

Literature - Encyclopedia of Medicines 2002.