Primary Septic Plague

Primary septicemic plague (p. primarioseptica)

Serous-primary septic plague is an acute infectious anthropozoonotic disease from the group of quarantine infections with a transmissible mechanism of pathogen transmission. Primary septicemic plague is characterized by a severe clinical course, caused by the rapid spread of infection through the lymphatic vessels of the body and the development of sepsis. The septic form of the disease is characteristic. The incubation period is 5-6 days. Diagnostic criteria for plague are based on clinical manifestations, epidemiological data and results of laboratory studies of microbial material. Treatment of patients is carried out by anti-plague institutions. Patients undergoing inpatient treatment are discharged after complete clinical recovery and a three-fold negative result of microscopic examination of biopsy samples of internal organs. In order to prevent the plague, a set of organizational, anti-epidemic and anti-plague measures are carried out, in accordance with sanitary rules and regulations. If plague is suspected, emergency prophylaxis with anti-plague chemoprophylaxis is used, which can be administered to persons from the contact group of the population or those in contact with the patient with the highest risk of infection. Emergency prevention of plague should be carried out simultaneously with the start of intensive specific therapy as soon as possible and until the patients recover or the final diagnosis is confirmed, or the fact of its complete ineffectiveness is established. Persons who have completed the full course of anti-plague treatment and are free of pathogens continue to be under dispensary observation for up to 2 months.

Causative agent of primary septicemic plague

This is an obligate pathogenic microbe; genus Yersinia. The causative agent of almost any form of plague is Yersina pestis - a microorganism of the genus Yersinia (rice), belonging to the department Gracilicutes, to the family Enterobacteriaceae, genus Yersinia, variety pestis (literally “tumor plague”), identified by V. N. Mitrokhin in the 3rd Gendle biological station All-Union Institute of Epidemiology and Microbiology named after. L. A. Tarasovich. This name for the infection was first proposed by M.A. Khodanskaya in 1894. Since then, the paired system of microbes has been finally established. Etiological role of Y. petaida sp. pestis was proven by T. I. Vinogradova et al. Nine genetically heterogeneous serovars of the pathogen have been identified: pre-Lindovia, Moscow, Pomir, Pacific, Antiminsk, Voznesensk, Nevsha-Morski, Kellin and Viamans, as well as 13 genetic clones, among which superficial ones are distinguished. Y. pestis II, extracellular determinant enzyme (DET) I, which breaks bacterial cells, Y. pestii 11, which is formed as a response to a toxin - streptotoxin, and DET III - which turns into DET II under the toxic effect of specific factors of the cell itself . Taken into account - I and hello

Primary septic plague is an infection characterized by high mortality, leading to high morbidity and mortality, which is characterized by generalized forms; the causative agent is bacterial flora.

Plague is a disease that affects a person. The source is an infected person or animal. The causative agent is a plague microbe, bacilli, which retain the ability to move after being exposed to low temperatures. They are characterized by hemolysis, spore formation and the absence of a cell wall when