Danistol

Country of origin: France
Pharm-Group: Calcium channel blockers of the phenylalkylamine group

Manufacturers: Etifarm (France)
International name: Verapamil
Synonyms: Atsupamil, Vepamil, Veracard, Veramil, Verapabene, Verapamil, Verapamil (Mival), Verapamil hydrochloride, Verapamil-MIK, Verapamil-Ratiopharm, Verapamil hydrochloride, Vero-Verapamil, Verogalid ER, Veromil, Isoptin, Isoptin SR, Kaveril, Lekoptin , Falicard, Fal
Dosage forms: capsules 120 mg, capsules 180 mg, capsules 240 mg
Composition: Active ingredient - Verapamil.

Indications for use: Paroxysmal supraventricular tachycardia (except WPW syndrome), sinus tachycardia, atrial extrasystole, atrial fibrillation and flutter, angina pectoris (including Prinzmetal, tension, post-infarction), arterial hypertension, hypertensive crisis, idiopathic hypertrophic subaortic stenosis, hypertrophic cardiomyopathy.

Contraindications: Hypersensitivity, severe hypotension, cardiogenic shock, AV block II and III degrees, myocardial infarction (acute or recent and complicated by bradycardia, hypotension, left ventricular failure), chronic heart failure stage III, WPW syndrome and sick sinus syndrome ( if a pacemaker is not implanted), sinoatrial blockade, Morgagni-Adams-Stokes syndrome, digitalis intoxication, severe stenosis of the aortic mouth, pregnancy, breastfeeding. Restrictions on use: AV block of the first degree, chronic heart failure stages I and II, severe bradycardia (less 50 beats/min), mild to moderate hypotension, severe myopathy (Duchenne syndrome), liver or kidney dysfunction, ventricular tachycardia with a wide QRS complex (for intravenous administration).

Side effect:

1. From the cardiovascular system and blood: hypotension, bradycardia, AV block, heart failure.

2. From the nervous system: headache, dizziness, nervousness, lethargy, drowsiness, weakness, fatigue, paresthesia.

3. From the gastrointestinal tract: nausea, dyspeptic symptoms, constipation; rarely - gingival hyperplasia, increased activity of liver transaminases and alkaline phosphatase.

4. Allergic reactions: skin rash, urticaria, itching; rarely - angioedema, Stevens-Johnson syndrome.

5. Other: facial skin flushing, bronchospasm, peripheral edema, gynecomastia, increased prolactin.

Interaction:

Interacts with digoxin, cyclosporine, theophylline, carbamazepine, lithium, rifampicin, phenobarbital, metoprolol, propranolol, muscle relaxants, diuretics, vasodilators, antidepressants, neuroleptics, nitrates, beta-blockers, antiarrhythmics, glycosides, anesthetics, radiocontrast agents, ace tilsalicylic acid, cimetidine.

Overdose: Hypotension, bradycardia, AV block, cardiogenic shock, coma, asystole. Treatment: calcium gluconate, atropine, isoprenaline.

Special instructions:

With long-term use, control Cl and bioavailability. Prescribe with caution in case of left ventricular obstruction, high pressure in the pulmonary capillaries, dysfunction of the liver, kidneys, or sinoatrial node. Avoid drinking alcohol.

Literature: Encyclopedia of Medicines 2003