Desmosome

The desmosome is a complex intercellular junction found primarily in epithelial tissue. At the points of contact, the cell membranes are thickened, and thin fibers - tonofibrils, attached to the sides of the plates facing the cytoplasm, are directed from the desmosome deep into the cytoplasm.

The desmosome performs the important function of mechanical adhesion of neighboring cells. Due to the presence of desmosomes, epithelial cells form a strong layer that can withstand tensile and shear loads. In addition to their mechanical function, desmosomes are involved in intercellular signaling and cell cycle regulation.

Disturbances in the structure and function of desmosomes lead to the development of a number of diseases. For example, congenital deficiency of desmosomal proteins causes epidermolysis bullosa, a skin disease characterized by the appearance of intraepidermal blisters. Studying the structure and functions of desmosomes is important for understanding the mechanisms of development of pathologies and finding methods for their treatment.

Desmosomes are complex intercellular junctions found primarily in epithelial tissues. These junctions play an important role in maintaining tissue integrity and ensuring the strength and stability of connections between cells.

Desmosomes consist of two plates that are located on opposite sides of cells. In the center between the plates is a dense layer of material that binds the cells together. This material is called desmin and consists of proteins such as desmin and α-actinin.

The cell membranes in desmosomes are thickened, which allows them to withstand heavy loads and maintain stable connections between cells. Thin fibers - tonofibrils - are attached to the sides of the plates facing the cytoplasm and are directed into the cytoplasm from the desmosomes.

An important property of desmosomes is their ability to regulate cell adhesion and migration. They are also involved in signaling between cells, which can influence cell growth, differentiation and survival.

In general, desmosomes play a key role in maintaining the structural integrity of tissues by ensuring the strength and stability of intercellular junctions.

Desmosomes, or desmasomes, are complex intercellular contacts that are found mainly in the tissues and cells of mammalian organisms. They are usually located between epithelial cells, but can also be found in nervous tissue and connective tissue.

There are several types of desmosomes: in the example of human brain cells, these are desmosome 1 and desmosome 2. A more detailed description of desmosomes is given below. **Type 1 desmosome** Type I desmosome is found, as mentioned above, in the tissue of nerve cells at the junction between neurons