Diazepam-Ratiofarm

Country of origin - Germany
Pharm-Group - Tranquilizers - benzodiazepine derivatives

Manufacturers - Ratiopharm GmbH (Germany)
International name - Diazepam
Synonyms - Apaurin, Apo-Diazepam, Valium, Valium Roche, Diazepabene, Diazepam, Diazepam Nycomed, Diazepam-Teva, Diazepex, Diapam, Dizep-5, Dicam, Kalmpose, Novo-Dipam, Relanium, Relium, Seduxen, Sibazon, Faustan
Dosage forms - solution for injection 10 mg, tablets 5 mg, tablets 10 mg
Composition - Active substance - diazepam.

Indications for use - Neuroses, neurasthenia, hysteria, reactive depression, agoraphobia, insomnia associated with a violation of the phase of falling asleep, Meniere's disease, spastic paralysis, withdrawal syndrome in patients with alcoholism, status epilepticus, epilepsy, premedication before surgical interventions and endoscopic manipulations; LSD poisoning.

Contraindications - Hypersensitivity, acute diseases of the liver and kidneys with impairment of their functions, myasthenia gravis, angle-closure glaucoma, first trimester of pregnancy, breastfeeding.

Side effect - Addiction, paradoxical reactions (development of anxiety, hallucinations, convulsions, insomnia), decreased reaction speed and concentration, drowsiness, deterioration of short-term memory, ataxia, dysarthria, headache, dizziness, hypotension, bradycardia, with prolonged use, liver damage and kidneys, intestinal atony, decreased libido and potency, reactions at the injection site, withdrawal syndrome, aftereffect syndrome (decreased performance, muscle weakness), allergic reactions.

Interaction - Potentiates the effects of alcohol, anticonvulsants and hypotensive drugs, analgesics, hypnotics. MAO inhibitors, analeptics, and psychostimulants reduce activity.

Overdose - Symptoms: drowsiness, impaired consciousness, coma, suppression of reflexes. Treatment: gastric lavage, intravenous fluids and flumazenil (a diazepine antagonist), artificial ventilation.

Special instructions - Mixing diazepam with other drugs in one syringe is not allowed, because the drug may settle on the walls. Avoid getting the solution into the artery and extravasal space. For intravenous administration to newborns, only large veins are used, and equipment for pulmonary resuscitation must be available.

Literature - Encyclopedia of Medicines 2002, Encyclopedia of Medicines 2002, Encyclopedia of Medicines 9th edition 2002.