Dobutamine Giulini

Dobutamine Giulini: instructions for use and features of the drug

Dobutamine Giulini is a medicine used to treat acute heart failure. The drug is a beta-adrenergic receptor stimulant and is produced in Germany by Giulini Pharma GmbH.

Dobutamine Giulini is available in the form of a lyophilized powder for the preparation of an injection solution in a dosage of 250 mg. The active substance is dobutamine.

Indications for use

Dobutamine Giulini is used to treat acute heart failure, including acute myocardial infarction, cardiogenic shock, exacerbation of chronic heart failure, and chronic heart failure as a temporary adjuvant.

Contraindications

The drug is contraindicated in case of hypersensitivity to dobutamine, idiopathic hypertrophic subaortic stenosis, pregnancy (restrictions on use), lactation.

Side effects

Various side effects may occur when using Dobutamine Giulini. These include headache, tachycardia, atrial fibrillation, pain in the heart and chest, palpitations, shortness of breath, increased blood pressure, hypotension, hypokalemia, inhibition of platelet aggregation (with long-term use), petechial bleeding, phlebitis; nausea; allergic reactions (skin rash, fever, bronchospasm, eosinophilia, polyuria); skin necrosis at the injection site.

Interaction

When Dobutamine Giulini is combined with sodium nitroprusside, a more pronounced decrease in OPSS and an increase in cardiac output is observed than when administered separately. Beta-blockers can reduce the positive inotropic effect, and an increase in peripheral vascular resistance is possible. The drug is pharmaceutically incompatible with ethanol, solutions containing sodium bisulfite, ethanol, sodium bicarbonate and other solutions with an alkaline reaction.

Overdose

In case of an overdose of Dobutamine Giulini, headache, shortness of breath, nausea, vomiting, anorexia, tremor, anxiety, palpitations, angina or cardialgia, tachyarrhythmia, severe hypertension, myocardial ischemia may occur. Treatment consists of stopping the drug and initiating appropriate symptomatic therapy.

Dosage and method of administration

The dosage of Dobutamine Giulini should be individual and determined depending on the indications for use, the patient’s condition, age and weight. Usually the drug is administered intravenously at a dose of 2.5-10 mcg/kg/minute. The infusion is carried out over 2-10 minutes, and then the dose is increased to an effective dose, which can reach 40 mcg/kg/minute.

Features of application

The use of Dobutamine Giulini requires constant monitoring of cardiac activity and hemodynamics. The drug should be used under the supervision of qualified medical personnel, as its improper use can lead to serious complications.

Conclusion

Dobutamine Giulini is an effective drug for the treatment of acute heart failure, but its use requires careful monitoring of the patient and control of the state of the cardiovascular system. If side effects occur, you should stop taking the drug and seek medical help.