Dopamine is a drug that is used to treat shock of various origins, including cardiogenic, postoperative, infectious-toxic, anaphylactic, hypovolemic (only after restoration of circulating blood volume), acute cardiovascular and renal failure, arterial hypotension and to enhance diuresis and accelerating the excretion of xenobiotics during poisoning. Dopamine belongs to the group of dopaminergic drugs.
Dopamine is produced in Russia by the companies GNIISKLS and Ferein, as well as in Ukraine by the company Darnitsa. The active ingredient of the drug is dopamine.
Dopamine is a neurotransmitter that is involved in the regulation of the central nervous system and the cardiovascular system. When dopamine is introduced into the body, the contractile function of the heart increases, diuresis increases and peripheral vascular resistance decreases.
Dopamine is available as an injection solution in various concentrations - 0.5% and 4%. The drug is used strictly under the supervision of a doctor, as it has a number of contraindications and side effects.
Contraindications for dopamine include pheochromocytoma, thyrotoxicosis, severe heart rhythm disturbances, peripheral vascular disease (with obliteration), prostate adenoma, bronchial asthma, and pregnancy. When using dopamine, side effects may occur such as nausea, vomiting, headache, anxiety, tremor, heart rhythm disturbances, angina pectoris, spasm of peripheral arteries, pain in the extremities, and arterial hypertension. When dopamine gets under the skin, necrosis can develop.
Dopamine is incompatible with ergot alkaloids, as this increases the risk of gangrene. Dopamine also enhances the effects of sympathomimetics, MAOIs and diuretics.
An overdose of dopamine may cause cardiac arrhythmias, tachycardia, and renal vasoconstriction.
In conclusion, dopamine is an effective drug in the treatment of shock of various origins and poisoning. However, its use should only be carried out under the supervision of a physician, taking into account possible contraindications and side effects.