Fibrinogenolysis of Cadaveric Blood

Article:

Fibrinogenolysis of cadaveric blood is the process of breakdown of fibrinogen in cadaveric blood under the action of the enzyme fibrinolysin.

Fibrinogen is a blood plasma protein that turns into fibrin strands during blood clotting. Fibrinolysin is an enzyme produced in the liver that lyses fibrinogen and fibrin.

After the death of a person, the activity of fibrinolysin increases sharply, which leads to the rapid breakdown of fibrinogen in the blood. This process is called fibrinogenolysis.

Fibrinogenolysis begins 2-4 hours after death and reaches a maximum after 10-24 hours. At the same time, the content of fibrinogen in the blood decreases, and its breakdown products (soluble fibrin-monomer complexes) increase.

The intensity of fibrinogenolysis depends on many factors - temperature, fibrinolysin activity, the presence of anticoagulants, etc. Determining the degree of fibrinogenolysis is used in forensic medicine to determine the duration of death.