Gastrosol

Country of origin: Russia, Pharmstandard-October Russia
Pharm-Group: Antiulcer drugs

Manufacturers: ICN October (Russia), Pharmstandard-October (Russia)
International name: Omeprazole
Synonyms: Vero-Omeprazole, Zerotsid, Zolser, Lokit, Lomak, Losek, Losek MAPS, Omegast, Omez, Omezol, Omepar, Omeprazole, Omeprazole-Akos, Omeprazole-Acri, Omeprazole-NS, Omeprazole-Oline, Omeprazole- Richter, Omeprazole-FPO, Omeprol, Omeprus, Omefez, Omizak, Omipix, Omito
Dosage forms: capsules 20 mg
Composition: Active ingredient - Omeprazole.

Indications for use: Peptic ulcer of the stomach and duodenum in the acute phase, gastroesophageal reflux disease, incl. refractory to therapy with H2-antihistamines, reflux esophagitis, incl. erosive and ulcerative, pathological hypersecretory conditions (Zollinger-Ellison syndrome, polyendocrine adenomatosis, systemic mastocytosis, stress ulcer, including prevention), peptic ulcer of the gastrointestinal tract caused by Helicobacter pylori, NSAID gastroenteropathy, erosive and ulcerative lesions of the stomach and duodenum in HIV-infected patients, non-ulcer dyspepsia.

Contraindications: Hypersensitivity, pregnancy, breastfeeding.

Side effect:

1. From the gastrointestinal tract: dry mouth, lack of appetite, nausea, vomiting, flatulence, abdominal pain, diarrhea, constipation, in some cases - changes in taste sensitivity, stomatitis and candidiasis of the gastrointestinal tract, polyposis of the fundus of the stomach, atrophic gastritis, increased activity of liver enzymes .

2. From the nervous system and sensory organs: headache, rarely - malaise, asthenia, dizziness, sleep disturbance, drowsiness, paresthesia, in some cases - restlessness, agitation, anxiety, depression, reversible mental disorders, hallucinations, visual impairment, incl. h. irreversible.

3. From the musculoskeletal system: in some cases - arthralgia, muscle weakness.

4. From the cardiovascular system and blood: in some cases - thrombocytopenia, leukopenia, neutropenia, eosinopenia, pancytopenia, leukocytosis, anemia.

5. From the genitourinary system: rarely - hematuria, proteinuria, peripheral edema, urinary tract infection.

6. From the skin: in some cases - photosensitivity, erythema multiforme, alopecia.

7. Allergic reactions: rarely - skin rash, urticaria, itching, in some cases - bronchospasm, angioedema, interstitial nephritis, anaphylactic shock.

8. Other: in some cases - chest pain, gynecomastia.

Interaction:

Changes the bioavailability of any drug whose absorption depends on pH (ketoconazole, iron salts, etc.). Slows down the elimination of drugs metabolized in the liver by microsomal oxidation (warfarin, diazepam, phenytoin, etc.).

Enhances the effect of coumarins and diphenine, does not change - NSAIDs. Increases (mutually) the blood concentration of clarithromycin. May increase the leukopenic and thrombocytopenic effects of drugs that inhibit hematopoiesis.

The substance for intravenous infusion is compatible only with saline and dextrose solution (when using other solvents, the stability of omeprazole may decrease due to changes in the pH of the infusion medium).

Overdose:

Symptoms: dry mouth, nausea, blurred vision, headache, increased sweating, flushing of the face, tachycardia, drowsiness, confusion.

Treatment: symptomatic; dialysis is ineffective.

Special instructions:

Restrictions on use. Chronic liver diseases, as well as childhood (claim