Gen-Salbutamol

Gene-salbutamol

Country of origin - Canada
Pharm-Group - Bronchodilators - beta-agonists

Manufacturers - Genfarm Inc (Canada)
International name - Salbutamol
Synonyms - Aloprol, Albuterol (Salbutamol), Asmadil, Astalin, Bronchovaleas, Ventodisk, Ventolin, Ventolin easy breathing, Ventolin Nebula, Volmax, Volmax, Salamol, Salamol easy breathing, Salamol Eco, Salamol Eco Easy Breathing, Salben, Salbuvent, Salbutamol
Dosage forms - solution for inhalation, dosed aerosol 100 mcg, dosed aerosol 200 dz, dosed aerosol 100 mcg/dose 200 dz
Composition - Active substance: Salbutamol.

Indications for use - Prevention and relief of bronchospasm in bronchial asthma, symptomatic treatment of broncho-obstructive syndrome (chronic bronchitis, chronic obstructive pulmonary disease, etc.), nocturnal asthma (long-acting tablet forms); prevention of premature birth.

Contraindications - Hypersensitivity, coronary artery disease, arterial hypertension, rhythm disturbances, heart failure, diabetes mellitus, hyperthyroidism, pheochromocytoma, renal dysfunction, first trimester of pregnancy.

Side effects - Dizziness, headache, tachycardia (during pregnancy - in mother and fetus), arrhythmia, hypotension, myocardial ischemia, heart failure, cardiopathy, pulmonary edema (possibly fatal), facial flushing, agitation, distal tremor, nausea, vomiting , dry mouth, loss of appetite, difficulty urinating, sweating, increased blood glucose, free fatty acids, hypokalemia, allergic reactions in the form of erythema, facial swelling, difficulty breathing, development of physical and mental drug dependence.

Interaction - Increases the activity of central nervous system stimulants, cardiotropism of thyroid hormones. Theophylline and ephedrine potentiate toxic effects. Corticosteroids, PG synthesis inhibitors, tricyclic antidepressants and MAO blockers increase the risk of developing cardiovascular complications, inhalation anesthesia and levodopa - severe ventricular arrhythmias. Reduces the effectiveness of beta blockers (including ophthalmic forms), antihypertensive drugs, and the antianginal effect of nitrates. Increases the likelihood of glycoside intoxication.

Overdose - Symptoms: tachycardia, ventricular flutter, peripheral vasodilation, decreased blood pressure, increased cardiac output, hypoxemia, acidosis, hypokalemia, hyperglycemia, muscle tremors, headache, agitation, hallucinations and other psychotic disorders.

Special instructions - Taking high doses of salbutamol during exacerbation of asthma leads to the fact that each subsequent attack of suffocation becomes more intense than the previous one. In case of a severe attack of suffocation, the break between inhalations should be at least 20 minutes. If there is no minimal effect from inhalation or the appearance of severe tremor, tachycardia, or cardiac arrhythmias, further uncontrolled use of the inhaler is contraindicated and you should consult a doctor. The risk of complications increases both with a significant duration of treatment and with abrupt discontinuation of the drug.

Literature - Encyclopedia of Medicines, 2003.