Glioral

Glioral: antidiabetic drug from Yugoslavia

Glioral (international name - gliclazide) is an antidiabetic drug, a sulfonylurea derivative, produced by ICN Galenika from Yugoslavia. It is used to treat type 2 diabetes mellitus, either alone or in combination with insulin or other oral hypoglycemic agents.

Glioral is available in the form of tablets containing 80 mg of the active substance - gliclazide. The drug has several synonyms, such as Vero-Gliclazide, Glidiab, Glizide, Diabest, Reklid, and others.

Like any other drug, Glioral has contraindications and side effects. Contraindications include hypersensitivity, type 1 diabetes mellitus (including juvenile diabetes), ketoacidosis, diabetic (with ketoacidosis) and hyperosmolar coma, liver failure and severe renal failure, hypo- and hyperthyroidism, pregnancy and lactation.

Side effects may include dyspeptic symptoms (nausea, vomiting, abdominal pain), jaundice, reversible cytopenia, eosinophilia, anemia, allergic skin reactions, photosensitivity, hypoglycemia, weakness, headache, dizziness, changes in taste, etc.

In addition, Glioral may interact with a number of other drugs, such as ACE inhibitors, beta-blockers, fibrates, chloramphenicol, cimetidine, coumarins, fenfluramine, fluoxetine, salicylates, guanethidine, MAO inhibitors, miconazole, fluconazole, pentoxifylline, theophylline, phenylbutazone, phosphamides, tetracyclines, etc.

An overdose of Glioral may cause hypoglycemic conditions, including coma, and cerebral edema. Treatment may include oral glucose or intravenous glucose solution (50%, 50 ml), as well as monitoring the level of glucose, urea nitrogen, and electrolytes in the blood serum.

To prevent hypoglycemia, it is recommended to strictly time the drug intake with meals, avoid fasting and completely stop drinking alcohol. It is also necessary to adhere to a low-calorie diet with limited intake of carbohydrates and fats, and regularly monitor blood glucose levels.

In general, the use of Glioral should only be carried out under the supervision of a physician and in accordance with his recommendations. Patients with diabetes need to regularly monitor their blood glucose levels, monitor their health, adhere to a healthy lifestyle and take all necessary measures to prevent complications.