Hestryna Method

The Hestrin method is a method for determining the activity of cholinesterase in blood serum, which is used to diagnose certain diseases such as Alzheimer's disease, Huntington's chorea and others. This method is based on determining the degree of hydrolysis of acetylcholine, a neurotransmitter that plays an important role in the transmission of nerve impulses.

To carry out the Hestrin method, a special solution containing acetylchlorine and hydroxylamine solution is used. When this solution is added to blood serum, a reaction occurs resulting in the formation of a colored product that can be determined by the colorimetric method. The degree of acetylcholine hydrolysis is determined by the color intensity of this product.

Studies have shown that the Hestrin method can diagnose Alzheimer's disease at an early stage, when symptoms have not yet appeared. This is due to the fact that cholinesterase activity decreases in this disease. In addition, the Hestrin method can be used to monitor the effectiveness of treatments for Alzheimer's disease and other diseases associated with impaired cholinesterase function.

In general, the Hestrin method is an important tool in the diagnosis and treatment of many diseases associated with blood cholinesterase activity. It is easy to use and relatively inexpensive, making it accessible to a wide range of patients.

The Hestrin method is a method for determining the activity of cholinesterase in blood serum. This method is used to diagnose various diseases associated with disruption of the nervous system.

Cholinesterase is an enzyme that plays an important role in the functioning of the nervous system. It is responsible for the destruction of acetylcholine, a neurotransmitter that is involved in the transmission of nerve impulses. If cholinesterase activity decreases, this can lead to various diseases such as Alzheimer's disease, Parkinson's disease and others.

The Hestrin method is based on measuring the degree of hydrolysis of acetylcholine. Acetylcholine is hydrolyzed by cholinesterase, and this process can be measured using a color reaction with hydroxylamine and ferric chloride. The result of the reaction is measured optically and expressed in units of cholinesterase activity.

The use of the hestrin method allows you to quickly and accurately determine the activity of cholinesterase and identify disturbances in the functioning of the nervous system at an early stage. This can help in diagnosing and treating various diseases.