Therapeutic Index

The therapeutic index is the ratio between the dosage of a drug that causes damage to healthy cells and the dosage that is necessary to achieve a certain level of antitumor effect of this substance. This ratio reflects the relative effectiveness of the antitumor treatment.

The higher the therapeutic index, the greater the advantage of the drug over its toxicity. That is, the higher the index, the safer and more effective the drug is considered.

The therapeutic index allows you to compare different drugs with each other based on the ratio of benefit and harm. It gives an idea of ​​how great the therapeutic effect of the drug is compared to its toxicity. This indicator is important for determining the optimal dosage of the drug.

The Therapeutic Index is an important indicator in assessing the effectiveness of drugs. This index allows you to determine the relationship between the therapeutic dose and the toxic dose of the drug, that is, the dose that causes damage to healthy cells in the body.

To achieve a certain level of antitumor effect, the drug must be used in a certain dose. However, if a dose exceeding the therapeutic dose is used, the drug may cause toxic effects and harm the patient's health. Therefore, it is important to determine a therapeutic dose that provides a sufficient level of antitumor effect but does not cause toxic effects.

The Therapeutic Index is calculated by dividing the toxic dose by the therapeutic dose. The higher the index value, the safer the drug substance, since the toxic dose will be significantly higher than the therapeutic dose. On the other hand, a low Therapeutic Index indicates that the drug substance may be dangerous and requires careful monitoring during use.

The Therapeutic Index is an important tool in the selection of drugs for the treatment of tumors. It allows you to choose the safest and most effective drug for a particular patient. In addition, the Therapeutic Index is used to assess the safety of drugs during clinical trials.

In conclusion, the Therapeutic Index is an important indicator in assessing the safety and effectiveness of drugs. It allows you to determine the relationship between therapeutic and toxic doses of a drug, which helps you choose the safest and most effective drug for treating tumors.

Therapeutic index

The therapeutic index (abbreviated as TI) is one of the most important parameters of drugs, assessing the ratio of the doses of the drug that cause harm to healthy cells and the doses that need to be increased to achieve an anticancer effect. In other words, TI is how accurately the drug is selected.

What is it for? There are two main methods for assessing TI: * In a hospital, the doctor sees the patient’s condition based on laboratory and clinical studies and determines the need for a particular dose of the drug. The stronger the application is required, the higher the therapeutic index. * During outpatient treatment, the doctor cannot directly contact the patient, but evaluates the result according to a previously drawn up treatment plan/treatment regimen. The choice of a drug with an increased therapeutic index should be carried out according to the scheme drawn up by the doctor, even if the patient recovers faster than expected. In this case, a high dose poses less of a health hazard.

The doctor should always monitor the patient’s well-being, because the treatment may be less effective and, as a result, the entire regimen may not be completed; as a result, the substance will cause more harm to health than good.