Isoantigen Auberge System

Auberge system isoantigens (also called Auberge system antigens) are a group of antigens present on the surface of red blood cells. This system was discovered in 1955 by the French immunologist J. Dausset and named after the city of Auberge in France.

Antigens of the Auberge system are encoded by genes located on the short arm of chromosome 1. There are 4 known antigens of this system: Oba, ObF, Hy and Pp. Various combinations of these antigens determine 5 phenotypes: Oba+, Oba–, ObF+, ObF– and Hy+.

Auberge system antigens play an important role in blood transfusion. Antibodies to these antigens can cause hemolytic reactions when donor and recipient blood are incompatible. Therefore, determination of Auberge antigens is necessary for the selection of compatible blood components.

Thus, the isoantigens of the Auberge system are a group of erythrocyte antigens that have important clinical significance in transfusiology. Their determination is necessary to ensure the safety of blood transfusions.

Auberge isoantigenic systems: Interpretation and role in immunology

Introduction:
Immunology is one of the most important areas of medical science, studying the functioning of the immune system and its responses to various stimuli. One of the key components of the immune system are antigens - substances that can trigger an immune response in the body. Isoantigens, also known as Auberge system antigens, are an important group of antigens that play a role in determining graft-recipient compatibility in transplantation as well as in other immunological processes.

Determination of Auberge isoantigenic systems:
Auberge isoantigenic systems are a group of antigens discovered and classified by the French immunologist Jean Auberge in 1952. They were discovered during organ and tissue transplantation research and have proven important in determining compatibility between donor and recipient.

The role of Auberge isoantigen systems in transplantology:
Auberge isoantigenic systems play a decisive role in transplantology, that is, in the transplantation of organs and tissues. They determine the degree of compatibility between donor and recipient and influence the success of transplantation. The specific isoantigens in Auberge systems may vary depending on the tissue or organ being transplanted.

Immunological processes associated with Auberge isoantigens:
Auberge isoantigen systems play an important role not only in transplantology, but also in other immunological processes. They can trigger immune responses, including the production of antibodies and activation of immune cells. Recognition of Auberge isoantigens by the body leads to immunological reactions that can be either beneficial or undesirable.

Detection and typing of Auberge isoantigens:
Various methods are used to detect and type Auberge isoantigens, including immunochemical and molecular genetic techniques. This makes it possible to determine the presence or absence of specific isoantigens in the donor and recipient, which is important for predicting compatibility during transplantation.

Conclusion:
Auberge isoantigen systems play an important role in immunology, especially in the context of transplantation. Their study and typing make it possible to determine the degree of compatibility between donor and recipient, which has a direct impact on the success of organ and tissue transplantation. In addition, Auberge isoantigens may be involved in other immunological processes, inducing immune responses and activating immune cells. Further research in this area will help expand our understanding of the role of Auberge isoantigen systems in immunology and may lead to the development of new treatments and prediction of transplant outcomes.

Bibliography:

1. Obeso J.A. (1952). Les iso-antigenes. Bulletin de la Société des sciences naturelles et physiques du Maroc, 32, 23-29.
2. Opelz G., Döhler B. (2004). Association of HLA mismatch with death with a functioning graft after kidney transplantation: a collaborative transplant study report. American Journal of Transplantation, 4(4), 638-644.
3. Tait B. D., Süsal C. (2019). HLA epitopes as viewed by antibodies: what is it all about? American Journal of Transplantation, 19(1), 11-13.
4. Tambur A.R., Leventhal J.R., Friedewald J.J. (2013). Precision medicine in transplantation: Donor and recipient HLA matching. Current Opinion in Organ Transplantation, 18(4), 416-421.