Kanamycin

Kanamycin: application, side effects and features

Kanamycin belongs to the group of aminoglycoside antibiotics and is widely used to treat various infectious diseases. In this article we will look at the main aspects of the use of kanamycin, its side effects and features.

Composition and mechanism of action

The active substance of kanamycin is kanamycin, which is produced by the microorganisms Streptomyces kanamyceticus. Kanamycin has a bactericidal effect by binding to the 30S subunit of the bacterial ribosome, which leads to disruption of protein synthesis and death of microorganisms.

Indications for use

Kanamycin is used in the treatment of various infectious diseases, including:

1. Sepsis
2. Meningitis
3. Peritonitis
4. Septic endocarditis
5. Pneumonia
6. Lung abscess
7. Empyema of the pleura
8. Kidney and urinary tract infections
9. Tuberculosis (with resistance to first and second line anti-tuberculosis drugs or in combination with other anti-tuberculosis drugs).

Contraindications

Kanamycin is contraindicated in case of hypersensitivity to this drug, as well as inflammation of the auditory nerve, impaired liver and kidney function, and intestinal obstruction. Restrictions on use apply to pregnant women, children in the first month of life and premature infants.

Side effects

Kanamycin may cause the following side effects:

1. Nausea
2. Vomiting
3. Loose stool
4. Acoustic neuritis
5. Neuromuscular blockade
6. Paresthesia
7. Liver dysfunction
8. Cylindruria
9. Microhematuria
10. Albuminuria.

Interaction with other drugs

There is no data on special interactions of kanamycin with other drugs, however, simultaneous use with other aminoglycosides is not recommended.

Overdose

There is no evidence of an overdose of kanamycin.

special instructions

When using kanamycin, it is necessary to monitor renal and auditory nerve function. Kanamycin is not recommended for use by pregnant women, as it can cross the placenta and cause toxic effects on the fetus. It is also not recommended to use kanamycin for children in the first month of life and premature infants.

conclusions

Kanamycin is an effective aminoglycoside antibiotic that is widely used in the treatment of various infectious diseases. However, its use may cause side effects, so it is necessary to strictly follow the doctor's recommendations and monitor the function of the kidneys and auditory nerve. In addition, kanamycin is not recommended for use by pregnant women and children in the first month of life and premature infants. In general, kanamycin is an effective drug when used correctly and monitored by a physician.