Clafobrine

Clafobrine: an effective antibiotic agent

Clafobrine, also known by the international name Cefotaxime, is one of the third generation cephalosporins. This drug has a broad spectrum of action and is used to treat severe bacterial infections caused by susceptible microorganisms. Clafobrine is produced in Russia by Bryntsalov-A and is one of the key drugs in the group of third-generation cephalosporins.

Clafobrine is presented on the pharmaceutical market under various trade names, such as Bayotax, Duatax, Intrataxime, Kefotex, Claforan, Clafotaxime, Liforan, Oritaxim, Resibelacta, Sephagen, Spirosin, Taxim, Talcef, Tarcefoxime, Tirotax, Haltex, Cetax, Cephabol, Cephajet, Cephantral, Cefosin, Cefotaxime, Cefotaxime sodium and Cefotaxime-M. This is an extensive list of synonyms, which indicates the wide distribution and popularity of the drug in clinical practice.

Clafobrine is available in two dosage forms: powder for the preparation of an intravenous solution weighing 1 g and powder for the preparation of an injection solution weighing 1 g. The main active ingredient of the drug is cefotaxime.

The drug is effective in the treatment of various infections, such as infections of the respiratory tract and ENT organs, infections of the skin and soft tissues, infected wounds and burns, infections of bones and joints, infections of the urinary tract, pelvic organs, obstetric and gynecological infections (including infections caused by microorganisms that secrete penicillinase, such as chlamydia and gonorrhea), bacteremia, septicemia, peritonitis, intra-abdominal infections, bacterial meningitis (except listeria), endocarditis, Lyme disease, typhoid fever and infections due to immunodeficiency. In addition, clafobrine can be used to prevent infections after surgery, including gastrointestinal surgery.

Despite its effectiveness, clafobrine has some contraindications. It is not recommended in case of hypersensitivity to penicillins, other cephalosporins or any other components of the drug. Caution should also be exercised when using clafobrine in patients with known allergic reactions to penicillins, as cross-sensitivity may occur.

Clafobrine is usually well tolerated, but like any medication, it can cause some side effects. Hypersensitivity reactions such as skin rash, itching, angioedema and anaphylactic shock are possible. Digestive disorders such as nausea, vomiting, diarrhea, dysbacteriosis and increased activity of liver enzymes may also occur.

The dosage and duration of clafobrine therapy depend on the type of infection, its severity and the sensitivity of the pathogen. The attending physician will determine the required dose and regimen of use of the drug in each specific case.

It is important to note that this information is current as of my cognitive cutoff in September 2021. Some aspects may change over time, so it is recommended that you consult your healthcare professional or consult current sources of information for the latest information about clafobrine or any other drug.